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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIAH2 All Species: 2.12
Human Site: T7 Identified Species: 3.89
UniProt: O43255 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43255 NP_005058.3 324 34615 T7 _ M S R P S S T G P S A N K P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_863586 282 31108
Cat Felis silvestris
Mouse Mus musculus Q06986 325 34739 G8 M S R P S S T G P S A N K P C
Rat Rattus norvegicus Q8R4T2 325 34681 G8 M S R P S S T G P S A N K P C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507643 433 47638 N119 R T E E A V K N F G E R T R R
Chicken Gallus gallus XP_426719 319 34023 A7 _ M S R P S S A G P G A S K P
Frog Xenopus laevis Q9I8X5 313 34081 A7 _ M S R P S S A G P C A S K P
Zebra Danio Brachydanio rerio Q7SYL3 331 34475 A16 G A A G G L G A G K A G G S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P21461 314 33689 P7 _ M S N K I N P K R R E P T A
Honey Bee Apis mellifera XP_394284 279 30558
Nematode Worm Caenorhab. elegans Q965X6 339 37641 V17 S T I S G T A V L G K T M A R
Sea Urchin Strong. purpuratus XP_797311 281 31248
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STN8 327 36556 T12 S M E C V S S T G N E I H Q N
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 70.6 N.A. 97.8 98.1 N.A. 56.5 91 85.8 76.1 N.A. 66.3 67.9 54.8 66.9
Protein Similarity: 100 N.A. N.A. 78.4 N.A. 97.8 98.1 N.A. 63.9 93.5 88.2 82.4 N.A. 76.8 76.8 66.9 76.2
P-Site Identity: 100 N.A. N.A. 0 N.A. 6.6 6.6 N.A. 0 78.5 78.5 6.6 N.A. 14.2 0 0 0
P-Site Similarity: 100 N.A. N.A. 0 N.A. 20 20 N.A. 6.6 85.7 85.7 26.6 N.A. 21.4 0 13.3 0
Percent
Protein Identity: N.A. N.A. N.A. 30.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 8 0 8 24 0 0 24 24 0 8 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 8 0 0 0 16 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 16 8 0 0 0 0 0 0 16 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 0 0 8 16 0 8 16 39 16 8 8 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 8 0 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 8 0 8 0 8 8 8 0 16 24 8 % K
% Leu: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % L
% Met: 16 39 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 8 0 0 8 8 0 8 0 16 8 0 8 % N
% Pro: 0 0 0 16 24 0 0 8 16 24 0 0 8 16 24 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 8 0 16 24 0 0 0 0 0 8 8 8 0 8 16 % R
% Ser: 16 16 31 8 16 47 31 0 0 16 8 0 16 8 0 % S
% Thr: 0 16 0 0 0 8 16 16 0 0 0 8 8 8 0 % T
% Val: 0 0 0 0 8 8 0 8 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 31 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _