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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRODH All Species: 25.45
Human Site: S478 Identified Species: 43.08
UniProt: O43272 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43272 NP_057419.3 516 59231 S478 M E V L P Y L S R R A L E N S
Chimpanzee Pan troglodytes XP_525525 354 39491 Y319 Y E A T N A M Y H R C L D Y V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534757 639 71930 S601 M D V L P Y L S R R A L E N S
Cat Felis silvestris
Mouse Mus musculus Q9WU79 497 56755 S459 M E V L P Y L S R R A L E N S
Rat Rattus norvegicus Q2V057 456 50984 Y421 C L E E V I P Y L I R R A Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234062 527 59659 R487 L E E I K H S R K A N V M V A
Frog Xenopus laevis Q6PAY6 466 52311 P431 G S V D S V L P Y L I R R A Q
Zebra Danio Brachydanio rerio XP_002665916 617 71033 S578 N E V I P Y L S R R A Q E N R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q04499 681 77135 S637 E E V L P Y L S R R A Q E N K
Honey Bee Apis mellifera XP_395275 528 60938 S484 K E V L P Y L S R R A Q E N R
Nematode Worm Caenorhab. elegans O45228 616 69804 S575 E E V L P Y L S R R A L E N G
Sea Urchin Strong. purpuratus XP_788908 295 34364 R260 V I P Y L S R R A Q E N S G M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92983 499 54937 I462 F G P V A T A I P Y L L R R A
Baker's Yeast Sacchar. cerevisiae P09368 476 53253 D441 G P P L E T K D Y L L R R L Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.9 N.A. 71.5 N.A. 81.9 32.5 N.A. N.A. 58 31.3 59.3 N.A. 39.6 47.7 40.9 37.9
Protein Similarity: 100 56 N.A. 76.8 N.A. 88.5 46.1 N.A. N.A. 69 48.4 70 N.A. 53.4 65.3 56.6 46.9
P-Site Identity: 100 20 N.A. 93.3 N.A. 100 0 N.A. N.A. 6.6 13.3 73.3 N.A. 80 80 86.6 0
P-Site Similarity: 100 33.3 N.A. 100 N.A. 100 0 N.A. N.A. 46.6 13.3 80 N.A. 80 80 86.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 25.9 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 8 8 8 0 8 8 50 0 8 8 15 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 8 0 8 0 0 0 8 0 0 0 0 8 0 0 % D
% Glu: 15 58 15 8 8 0 0 0 0 0 8 0 50 0 8 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 8 0 0 0 0 0 0 0 0 0 0 0 8 8 % G
% His: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 8 0 15 0 8 0 8 0 8 8 0 0 0 0 % I
% Lys: 8 0 0 0 8 0 8 0 8 0 0 0 0 0 8 % K
% Leu: 8 8 0 50 8 0 58 0 8 15 15 43 0 8 0 % L
% Met: 22 0 0 0 0 0 8 0 0 0 0 0 8 0 8 % M
% Asn: 8 0 0 0 8 0 0 0 0 0 8 8 0 50 0 % N
% Pro: 0 8 22 0 50 0 8 8 8 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 0 22 0 8 15 % Q
% Arg: 0 0 0 0 0 0 8 15 50 58 8 22 22 8 15 % R
% Ser: 0 8 0 0 8 8 8 50 0 0 0 0 8 0 22 % S
% Thr: 0 0 0 8 0 15 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 58 8 8 8 0 0 0 0 0 8 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 8 0 50 0 15 15 8 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _