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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRODH All Species: 14.85
Human Site: S486 Identified Species: 25.13
UniProt: O43272 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43272 NP_057419.3 516 59231 S486 R R A L E N S S L M K G T H R
Chimpanzee Pan troglodytes XP_525525 354 39491 L327 H R C L D Y V L E E L K H N A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534757 639 71930 S609 R R A L E N S S V M K G A W R
Cat Felis silvestris
Mouse Mus musculus Q9WU79 497 56755 S467 R R A L E N S S I M K G A Q R
Rat Rattus norvegicus Q2V057 456 50984 N429 L I R R A Q E N R S V L Q G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234062 527 59659 T495 K A N V M V A T H N E D T V K
Frog Xenopus laevis Q6PAY6 466 52311 E439 Y L I R R A Q E N Q S V L Q G
Zebra Danio Brachydanio rerio XP_002665916 617 71033 G586 R R A Q E N R G F M K G S Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q04499 681 77135 G645 R R A Q E N K G V L K K I K K
Honey Bee Apis mellifera XP_395275 528 60938 G492 R R A Q E N R G I L K K I K K
Nematode Worm Caenorhab. elegans O45228 616 69804 S583 R R A L E N G S V L K K A N K
Sea Urchin Strong. purpuratus XP_788908 295 34364 L268 A Q E N S G M L K G V T Q E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92983 499 54937 Y470 P Y L L R R A Y E N R G M M A
Baker's Yeast Sacchar. cerevisiae P09368 476 53253 E449 Y L L R R L Q E N G D A V R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.9 N.A. 71.5 N.A. 81.9 32.5 N.A. N.A. 58 31.3 59.3 N.A. 39.6 47.7 40.9 37.9
Protein Similarity: 100 56 N.A. 76.8 N.A. 88.5 46.1 N.A. N.A. 69 48.4 70 N.A. 53.4 65.3 56.6 46.9
P-Site Identity: 100 13.3 N.A. 80 N.A. 80 0 N.A. N.A. 6.6 0 60 N.A. 40 40 53.3 6.6
P-Site Similarity: 100 26.6 N.A. 86.6 N.A. 86.6 6.6 N.A. N.A. 46.6 0 66.6 N.A. 60 60 80 13.3
Percent
Protein Identity: N.A. N.A. N.A. 25.9 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 50 0 8 8 15 0 0 0 0 8 22 0 22 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 0 8 8 0 0 0 % D
% Glu: 0 0 8 0 50 0 8 15 15 8 8 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 22 0 15 0 36 0 8 8 % G
% His: 8 0 0 0 0 0 0 0 8 0 0 0 8 8 0 % H
% Ile: 0 8 8 0 0 0 0 0 15 0 0 0 15 0 0 % I
% Lys: 8 0 0 0 0 0 8 0 8 0 50 29 0 15 29 % K
% Leu: 8 15 15 43 0 8 0 15 8 22 8 8 8 0 0 % L
% Met: 0 0 0 0 8 0 8 0 0 29 0 0 8 8 0 % M
% Asn: 0 0 8 8 0 50 0 8 15 15 0 0 0 15 0 % N
% Pro: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 22 0 8 15 0 0 8 0 0 15 22 0 % Q
% Arg: 50 58 8 22 22 8 15 0 8 0 8 0 0 8 36 % R
% Ser: 0 0 0 0 8 0 22 29 0 8 8 0 8 0 8 % S
% Thr: 0 0 0 0 0 0 0 8 0 0 0 8 15 0 0 % T
% Val: 0 0 0 8 0 8 8 0 22 0 15 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 15 8 0 0 0 8 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _