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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRODH All Species: 8.18
Human Site: Y459 Identified Species: 13.85
UniProt: O43272 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43272 NP_057419.3 516 59231 Y459 F P L G Q A G Y P V Y K Y V P
Chimpanzee Pan troglodytes XP_525525 354 39491 A300 A Q E R A C A A E I G Y E D P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534757 639 71930 F582 F P L G Q A G F P V Y K Y V P
Cat Felis silvestris
Mouse Mus musculus Q9WU79 497 56755 F440 F P L G Q A G F P V Y K Y V P
Rat Rattus norvegicus Q2V057 456 50984 A402 V S L A L G Q A G Y M V Y K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234062 527 59659 T468 I N P T Y E K T N E M Y H R C
Frog Xenopus laevis Q6PAY6 466 52311 Q412 H V S L T L G Q A G Y L V Y K
Zebra Danio Brachydanio rerio XP_002665916 617 71033 F559 F P L G Q A G F P V Y K Y V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q04499 681 77135 Y618 F P L G Q A G Y S A Y K Y I P
Honey Bee Apis mellifera XP_395275 528 60938 Y465 F P L G Q S G Y S A Y K Y I P
Nematode Worm Caenorhab. elegans O45228 616 69804 F556 F S L G Q A G F S V Y K Y L P
Sea Urchin Strong. purpuratus XP_788908 295 34364 V241 L G E M G Y A V Y K Y V P Y G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92983 499 54937 K443 D A L S F G L K R A G F N V S
Baker's Yeast Sacchar. cerevisiae P09368 476 53253 H422 T Y D L I T N H G A K N I I K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.9 N.A. 71.5 N.A. 81.9 32.5 N.A. N.A. 58 31.3 59.3 N.A. 39.6 47.7 40.9 37.9
Protein Similarity: 100 56 N.A. 76.8 N.A. 88.5 46.1 N.A. N.A. 69 48.4 70 N.A. 53.4 65.3 56.6 46.9
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 93.3 13.3 N.A. N.A. 0 13.3 93.3 N.A. 80 73.3 73.3 6.6
P-Site Similarity: 100 13.3 N.A. 100 N.A. 100 13.3 N.A. N.A. 6.6 13.3 100 N.A. 86.6 86.6 86.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. 25.9 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. 44.5 38.9 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 8 43 15 15 8 29 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % C
% Asp: 8 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 15 0 0 8 0 0 8 8 0 0 8 0 0 % E
% Phe: 50 0 0 0 8 0 0 29 0 0 0 8 0 0 0 % F
% Gly: 0 8 0 50 8 15 58 0 15 8 15 0 0 0 8 % G
% His: 8 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % H
% Ile: 8 0 0 0 8 0 0 0 0 8 0 0 8 22 0 % I
% Lys: 0 0 0 0 0 0 8 8 0 8 8 50 0 8 15 % K
% Leu: 8 0 65 15 8 8 8 0 0 0 0 8 0 8 0 % L
% Met: 0 0 0 8 0 0 0 0 0 0 15 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 8 0 8 0 0 8 8 0 0 % N
% Pro: 0 43 8 0 0 0 0 0 29 0 0 0 8 0 58 % P
% Gln: 0 8 0 0 50 0 8 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 8 0 0 0 0 8 0 % R
% Ser: 0 15 8 8 0 8 0 0 22 0 0 0 0 0 15 % S
% Thr: 8 0 0 8 8 8 0 8 0 0 0 0 0 0 0 % T
% Val: 8 8 0 0 0 0 0 8 0 36 0 15 8 36 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 8 0 22 8 8 65 15 58 15 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _