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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K13
All Species:
11.52
Human Site:
S586
Identified Species:
21.11
UniProt:
O43283
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43283
NP_004712.1
966
108296
S586
S
S
K
S
R
Y
R
S
K
P
R
H
R
R
G
Chimpanzee
Pan troglodytes
XP_001150116
966
108442
S586
S
S
K
S
R
Y
R
S
K
P
R
H
R
R
G
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
E520
L
L
H
G
N
T
M
E
K
L
I
K
K
R
N
Dog
Lupus familis
XP_848815
893
96248
I523
G
N
T
M
E
K
L
I
K
K
R
N
V
P
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q1HKZ5
959
106968
S585
S
S
R
S
R
Y
R
S
K
P
R
H
R
R
G
Rat
Rattus norvegicus
Q63796
888
96289
T518
R
S
L
L
H
G
N
T
M
E
K
L
I
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508287
535
59838
L165
G
S
G
S
G
G
F
L
E
G
L
F
G
C
L
Chicken
Gallus gallus
Frog
Xenopus laevis
A7J1T0
961
107551
G583
S
P
K
T
S
S
G
G
G
K
G
R
Y
R
S
Zebra Danio
Brachydanio rerio
XP_696830
983
109314
R606
P
K
R
P
D
L
L
R
S
D
G
I
P
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
Q590
A
P
N
L
D
K
K
Q
Q
Q
Q
N
Q
Q
Q
Honey Bee
Apis mellifera
XP_397605
895
101116
P525
T
S
S
T
P
T
T
P
P
S
P
T
D
C
P
Nematode Worm
Caenorhab. elegans
O01700
928
103465
S549
P
F
S
R
Q
S
S
S
R
S
S
A
G
Q
Q
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
R565
R
A
K
T
L
P
Q
R
K
S
R
H
R
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
50.8
50.8
N.A.
88.7
50
N.A.
46
N.A.
69.2
67.9
N.A.
23.7
35.9
27.4
37
Protein Similarity:
100
99.3
63.7
63.4
N.A.
93.2
63.4
N.A.
47.8
N.A.
78.9
76.3
N.A.
40
52.2
44
53.2
P-Site Identity:
100
100
13.3
13.3
N.A.
93.3
6.6
N.A.
13.3
N.A.
20
0
N.A.
0
6.6
6.6
40
P-Site Similarity:
100
100
20
26.6
N.A.
100
26.6
N.A.
20
N.A.
26.6
6.6
N.A.
46.6
20
26.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% C
% Asp:
0
0
0
0
16
0
0
0
0
8
0
0
8
0
0
% D
% Glu:
0
0
0
0
8
0
0
8
8
8
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
8
0
0
0
0
8
0
0
0
% F
% Gly:
16
0
8
8
8
16
8
8
8
8
16
0
16
0
24
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
31
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
8
8
8
0
0
% I
% Lys:
0
8
31
0
0
16
8
0
47
16
8
8
8
8
8
% K
% Leu:
8
8
8
16
8
8
16
8
0
8
8
8
0
0
8
% L
% Met:
0
0
0
8
0
0
8
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
8
0
0
0
0
16
0
0
16
% N
% Pro:
16
16
0
8
8
8
0
8
8
24
8
0
8
8
8
% P
% Gln:
0
0
0
0
8
0
8
8
8
8
8
0
8
16
24
% Q
% Arg:
16
0
16
8
24
0
24
16
8
0
39
8
31
47
0
% R
% Ser:
31
47
16
31
8
16
8
31
8
24
8
0
0
8
8
% S
% Thr:
8
0
8
24
0
16
8
8
0
0
0
8
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
24
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _