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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K13
All Species:
13.33
Human Site:
T546
Identified Species:
24.44
UniProt:
O43283
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43283
NP_004712.1
966
108296
T546
P
H
K
S
G
M
Q
T
K
R
P
D
L
L
R
Chimpanzee
Pan troglodytes
XP_001150116
966
108442
T546
P
H
K
S
G
M
Q
T
K
R
P
D
L
L
R
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
M480
Y
M
E
L
N
A
L
M
L
Q
L
E
L
K
E
Dog
Lupus familis
XP_848815
893
96248
L483
L
N
A
L
M
L
Q
L
E
L
K
E
R
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q1HKZ5
959
106968
T545
P
H
K
A
G
V
Q
T
K
R
P
D
L
L
R
Rat
Rattus norvegicus
Q63796
888
96289
A478
N
L
Y
M
E
L
N
A
L
M
L
Q
L
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508287
535
59838
D125
V
L
Q
L
R
E
Q
D
E
A
E
P
A
G
P
Chicken
Gallus gallus
Frog
Xenopus laevis
A7J1T0
961
107551
S543
I
K
K
K
G
P
P
S
R
V
P
S
Q
S
K
Zebra Danio
Brachydanio rerio
XP_696830
983
109314
Y566
E
K
K
Y
P
G
T
Y
K
R
H
L
V
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
M550
K
T
W
G
P
S
T
M
H
Q
R
E
R
S
L
Honey Bee
Apis mellifera
XP_397605
895
101116
E485
E
R
D
V
I
K
R
E
Q
Q
N
G
Y
K
Q
Nematode Worm
Caenorhab. elegans
O01700
928
103465
G509
L
R
G
Y
P
N
E
G
Y
D
D
M
S
S
D
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
S525
G
S
A
T
L
G
R
S
P
S
P
G
S
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
50.8
50.8
N.A.
88.7
50
N.A.
46
N.A.
69.2
67.9
N.A.
23.7
35.9
27.4
37
Protein Similarity:
100
99.3
63.7
63.4
N.A.
93.2
63.4
N.A.
47.8
N.A.
78.9
76.3
N.A.
40
52.2
44
53.2
P-Site Identity:
100
100
6.6
6.6
N.A.
86.6
6.6
N.A.
6.6
N.A.
20
20
N.A.
0
0
0
6.6
P-Site Similarity:
100
100
26.6
33.3
N.A.
100
13.3
N.A.
20
N.A.
40
26.6
N.A.
13.3
26.6
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
8
0
8
0
8
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
8
0
8
8
24
0
0
8
% D
% Glu:
16
0
8
0
8
8
8
8
16
0
8
24
0
16
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
8
31
16
0
8
0
0
0
16
0
8
0
% G
% His:
0
24
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
16
39
8
0
8
0
0
31
0
8
0
0
16
8
% K
% Leu:
16
16
0
24
8
16
8
8
16
8
16
8
39
24
24
% L
% Met:
0
8
0
8
8
16
0
16
0
8
0
8
0
0
0
% M
% Asn:
8
8
0
0
8
8
8
0
0
0
8
0
0
0
0
% N
% Pro:
24
0
0
0
24
8
8
0
8
0
39
8
0
0
16
% P
% Gln:
0
0
8
0
0
0
39
0
8
24
0
8
8
0
8
% Q
% Arg:
0
16
0
0
8
0
16
0
8
31
8
0
16
8
24
% R
% Ser:
0
8
0
16
0
8
0
16
0
8
0
8
16
31
8
% S
% Thr:
0
8
0
8
0
0
16
24
0
0
0
0
0
0
0
% T
% Val:
8
0
0
8
0
8
0
0
0
8
0
0
8
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
16
0
0
0
8
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _