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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K13
All Species:
21.82
Human Site:
Y422
Identified Species:
40
UniProt:
O43283
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43283
NP_004712.1
966
108296
Y422
L
A
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
Chimpanzee
Pan troglodytes
XP_001150116
966
108442
Y422
L
A
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
R391
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
Dog
Lupus familis
XP_848815
893
96248
L394
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q1HKZ5
959
106968
Y421
L
A
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
Rat
Rattus norvegicus
Q63796
888
96289
S389
R
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508287
535
59838
L36
S
A
A
L
E
P
F
L
P
T
G
L
G
L
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
A7J1T0
961
107551
Y425
L
G
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
Zebra Danio
Brachydanio rerio
XP_696830
983
109314
Y473
L
G
T
P
Q
E
T
Y
F
K
C
Q
T
E
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
S414
F
T
L
T
P
Q
E
S
F
H
Y
M
Q
E
C
Honey Bee
Apis mellifera
XP_397605
895
101116
L396
G
I
A
A
V
E
V
L
C
T
K
P
D
D
Y
Nematode Worm
Caenorhab. elegans
O01700
928
103465
P407
F
A
K
C
I
Q
Y
P
S
T
V
T
R
D
H
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
Y400
L
S
T
P
Q
E
A
Y
F
D
K
Q
V
D
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
50.8
50.8
N.A.
88.7
50
N.A.
46
N.A.
69.2
67.9
N.A.
23.7
35.9
27.4
37
Protein Similarity:
100
99.3
63.7
63.4
N.A.
93.2
63.4
N.A.
47.8
N.A.
78.9
76.3
N.A.
40
52.2
44
53.2
P-Site Identity:
100
100
0
0
N.A.
100
6.6
N.A.
6.6
N.A.
93.3
80
N.A.
13.3
6.6
6.6
60
P-Site Similarity:
100
100
0
20
N.A.
100
13.3
N.A.
13.3
N.A.
93.3
80
N.A.
20
20
20
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
39
16
8
0
0
8
0
0
0
0
0
31
8
0
% A
% Cys:
0
0
0
8
0
0
0
0
8
0
8
0
0
0
8
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
8
8
24
8
% D
% Glu:
0
0
0
0
8
54
8
0
0
0
0
0
0
47
0
% E
% Phe:
16
0
0
8
0
0
16
0
62
0
0
0
0
0
0
% F
% Gly:
8
16
0
0
0
0
0
0
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
16
0
0
8
0
16
% H
% Ile:
0
8
0
0
8
0
8
0
0
8
0
8
8
0
0
% I
% Lys:
0
8
8
0
0
0
0
0
0
39
16
0
0
0
0
% K
% Leu:
47
0
8
8
0
0
0
24
8
0
16
16
8
24
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
8
8
47
16
8
8
8
8
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
47
24
0
0
8
0
8
47
8
0
8
% Q
% Arg:
16
8
0
16
8
8
0
8
0
8
0
0
8
0
0
% R
% Ser:
8
8
8
0
0
8
0
16
8
0
31
0
0
0
8
% S
% Thr:
0
8
47
8
0
0
39
0
0
24
0
8
8
0
0
% T
% Val:
0
0
0
0
8
0
8
0
0
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
47
% W
% Tyr:
0
0
0
0
0
0
8
47
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _