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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSPA12A All Species: 40.3
Human Site: Y537 Identified Species: 98.52
UniProt: O43301 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43301 NP_079291.2 675 74978 Y537 V R R S P L T Y G V G V L N R
Chimpanzee Pan troglodytes XP_529348 668 74301 Y530 V R R S P L T Y G V G V L N R
Rhesus Macaque Macaca mulatta XP_001095628 812 89841 Y674 V R R S P L T Y G V G V L N R
Dog Lupus familis XP_544034 744 81944 Y606 V R R S P L T Y G V G V L N R
Cat Felis silvestris
Mouse Mus musculus Q8K0U4 675 74853 Y537 V R R S P L T Y G V G V L N R
Rat Rattus norvegicus NP_001100915 675 74812 Y537 V R R S P L T Y G V G V L N R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512019 674 75027 Y536 V R R S P L T Y G V G V L N R
Chicken Gallus gallus XP_421779 670 74732 Y533 V R R S P L T Y G V G V L N R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001036151 691 77339 Y543 V R R C P L T Y G V G V L N R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780658 1340 145466 Y1202 V R R S R L T Y G V G V L N K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 82.6 88.3 N.A. 96.4 96.8 N.A. 90.6 88.4 N.A. 62.3 N.A. N.A. N.A. N.A. 26.4
Protein Similarity: 100 98.5 82.8 89.7 N.A. 98.2 98.5 N.A. 95.4 94.2 N.A. 78.7 N.A. N.A. N.A. N.A. 36.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 93.3 N.A. N.A. N.A. N.A. 86.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 N.A. 93.3 N.A. N.A. N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 100 0 100 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % K
% Leu: 0 0 0 0 0 100 0 0 0 0 0 0 100 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % N
% Pro: 0 0 0 0 90 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 100 100 0 10 0 0 0 0 0 0 0 0 0 90 % R
% Ser: 0 0 0 90 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 100 0 0 0 0 0 0 0 0 % T
% Val: 100 0 0 0 0 0 0 0 0 100 0 100 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _