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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF3
All Species:
37.88
Human Site:
S538
Identified Species:
64.1
UniProt:
O43395
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43395
NP_004689.1
683
77529
S538
K
K
L
K
E
D
I
S
Q
G
V
H
I
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101105
683
77496
S538
K
K
L
K
E
D
I
S
Q
G
V
H
I
S
V
Dog
Lupus familis
XP_860581
685
77562
S540
K
K
L
K
E
D
I
S
Q
G
V
H
I
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q922U1
683
77436
S538
K
K
L
K
E
D
I
S
Q
G
V
H
I
S
V
Rat
Rattus norvegicus
NP_001102029
637
72177
E513
K
R
Q
K
A
H
E
E
A
N
A
A
R
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509322
682
76176
S541
R
K
L
K
E
D
L
S
H
G
V
H
L
S
V
Chicken
Gallus gallus
Q5ZJ85
684
77367
S539
K
K
L
K
E
D
V
S
Q
G
V
H
I
A
V
Frog
Xenopus laevis
NP_001085273
679
76844
D534
K
V
K
K
L
K
E
D
I
S
Q
G
I
H
V
Zebra Danio
Brachydanio rerio
NP_991311
700
78843
S558
K
K
L
K
E
D
L
S
H
G
V
H
I
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649156
598
67364
S458
R
K
L
R
E
D
T
S
C
G
V
H
V
S
V
Honey Bee
Apis mellifera
XP_392148
633
72356
T492
R
K
L
K
E
D
T
T
L
G
V
H
V
A
V
Nematode Worm
Caenorhab. elegans
NP_499300
621
71178
S474
K
K
L
S
E
D
T
S
T
A
V
N
V
S
V
Sea Urchin
Strong. purpuratus
XP_780513
572
64792
R448
N
L
N
N
P
A
K
R
F
K
V
E
A
N
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03338
469
55852
P350
Q
F
K
N
L
Q
N
P
K
I
R
F
K
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.8
98.6
N.A.
99.5
90.7
N.A.
66.1
94.4
86.3
71.5
N.A.
48.3
52.2
35.8
49.6
Protein Similarity:
100
N.A.
100
98.8
N.A.
99.7
91.9
N.A.
78.9
97.9
93.5
83.8
N.A.
62.9
68.5
55.4
62.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
73.3
86.6
26.6
80
N.A.
66.6
60
60
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
26.6
N.A.
93.3
100
26.6
93.3
N.A.
86.6
86.6
73.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
8
8
8
8
8
22
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
72
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
72
0
15
8
0
0
0
8
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
8
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
65
0
8
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
15
0
0
65
0
8
0
% H
% Ile:
0
0
0
0
0
0
29
0
8
8
0
0
50
0
0
% I
% Lys:
65
72
15
72
0
8
8
0
8
8
0
0
8
8
8
% K
% Leu:
0
8
72
0
15
0
15
0
8
0
0
0
8
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
15
0
0
8
0
0
8
0
8
0
8
0
% N
% Pro:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
0
8
0
0
36
0
8
0
0
0
0
% Q
% Arg:
22
8
0
8
0
0
0
8
0
0
8
0
8
0
0
% R
% Ser:
0
0
0
8
0
0
0
65
0
8
0
0
0
50
0
% S
% Thr:
0
0
0
0
0
0
22
8
8
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
8
0
0
0
79
0
22
0
79
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _