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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF3
All Species:
22.12
Human Site:
S619
Identified Species:
37.44
UniProt:
O43395
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43395
NP_004689.1
683
77529
S619
K
G
D
D
D
E
E
S
D
E
E
A
V
K
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101105
683
77496
S619
K
G
D
D
D
E
E
S
D
E
E
A
V
K
K
Dog
Lupus familis
XP_860581
685
77562
S621
K
G
D
D
D
E
E
S
D
E
E
A
V
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q922U1
683
77436
S619
K
G
D
D
D
E
E
S
D
E
E
A
V
K
K
Rat
Rattus norvegicus
NP_001102029
637
72177
G571
A
G
Q
L
Y
L
T
G
V
V
V
L
H
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509322
682
76176
R618
E
P
G
G
R
G
H
R
I
E
E
E
A
R
K
Chicken
Gallus gallus
Q5ZJ85
684
77367
S620
K
G
E
D
D
D
E
S
D
E
E
S
V
K
K
Frog
Xenopus laevis
NP_001085273
679
76844
S615
K
G
K
D
N
D
E
S
D
E
E
S
V
P
K
Zebra Danio
Brachydanio rerio
NP_991311
700
78843
P635
N
S
K
R
D
E
H
P
D
A
D
E
S
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649156
598
67364
K531
K
W
E
E
D
N
A
K
G
N
D
G
Q
D
V
Honey Bee
Apis mellifera
XP_392148
633
72356
K565
K
W
E
E
D
I
I
K
D
N
D
G
N
D
V
Nematode Worm
Caenorhab. elegans
NP_499300
621
71178
A551
I
I
G
Q
K
K
D
A
E
K
D
A
P
G
E
Sea Urchin
Strong. purpuratus
XP_780513
572
64792
D507
R
S
K
H
D
D
D
D
S
G
D
E
A
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03338
469
55852
E407
I
K
W
N
E
D
F
E
L
H
T
N
T
G
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.8
98.6
N.A.
99.5
90.7
N.A.
66.1
94.4
86.3
71.5
N.A.
48.3
52.2
35.8
49.6
Protein Similarity:
100
N.A.
100
98.8
N.A.
99.7
91.9
N.A.
78.9
97.9
93.5
83.8
N.A.
62.9
68.5
55.4
62.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
20
80
66.6
20
N.A.
13.3
20
6.6
13.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
33.3
100
86.6
40
N.A.
33.3
40
53.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
8
0
8
0
36
15
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
29
43
65
29
15
8
58
0
36
0
0
15
15
% D
% Glu:
8
0
22
15
8
36
43
8
8
50
50
22
0
0
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
50
15
8
0
8
0
8
8
8
0
15
0
15
0
% G
% His:
0
0
0
8
0
0
15
0
0
8
0
0
8
0
0
% H
% Ile:
15
8
0
0
0
8
8
0
8
0
0
0
0
0
0
% I
% Lys:
58
8
22
0
8
8
0
15
0
8
0
0
0
43
58
% K
% Leu:
0
0
0
8
0
8
0
0
8
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
8
8
8
0
0
0
15
0
8
8
0
0
% N
% Pro:
0
8
0
0
0
0
0
8
0
0
0
0
8
8
0
% P
% Gln:
0
0
8
8
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
8
0
0
8
8
0
0
8
0
0
0
0
0
15
8
% R
% Ser:
0
15
0
0
0
0
0
43
8
0
0
15
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
8
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
8
8
8
0
43
8
15
% V
% Trp:
0
15
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _