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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF3 All Species: 41.82
Human Site: T435 Identified Species: 70.77
UniProt: O43395 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43395 NP_004689.1 683 77529 T435 V D N D T P V T L G V Y L T K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001101105 683 77496 T435 V D N D T P V T L G V Y L T K
Dog Lupus familis XP_860581 685 77562 T437 V D N D T P V T L G V Y L T K
Cat Felis silvestris
Mouse Mus musculus Q922U1 683 77436 T435 V D N D T P V T L G V Y L T K
Rat Rattus norvegicus NP_001102029 637 72177 T435 V D N D T P V T L G V Y L T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509322 682 76176 T438 L D T T T P V T L P V Y L T K
Chicken Gallus gallus Q5ZJ85 684 77367 T436 V D S D T P V T L G V Y L T K
Frog Xenopus laevis NP_001085273 679 76844 T433 V D K D A P V T L G I Y L T K
Zebra Danio Brachydanio rerio NP_991311 700 78843 T455 V D T D K P V T L G V Y L T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649156 598 67364 Y355 N E P L K P V Y L P V F L T K
Honey Bee Apis mellifera XP_392148 633 72356 Y389 T D P L K P I Y M P V F L T K
Nematode Worm Caenorhab. elegans NP_499300 621 71178 Y371 T E P L T Q Q Y L K V Y L T T
Sea Urchin Strong. purpuratus XP_780513 572 64792 R368 P P P E P K V R M A N L M R V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03338 469 55852 K273 P K P E P K V K L S N M M S V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.8 98.6 N.A. 99.5 90.7 N.A. 66.1 94.4 86.3 71.5 N.A. 48.3 52.2 35.8 49.6
Protein Similarity: 100 N.A. 100 98.8 N.A. 99.7 91.9 N.A. 78.9 97.9 93.5 83.8 N.A. 62.9 68.5 55.4 62.5
P-Site Identity: 100 N.A. 100 100 N.A. 100 100 N.A. 73.3 93.3 80 86.6 N.A. 46.6 40 40 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 80 100 86.6 86.6 N.A. 60 60 46.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 72 0 58 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 15 0 15 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 58 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % I
% Lys: 0 8 8 0 22 15 0 8 0 8 0 0 0 0 79 % K
% Leu: 8 0 0 22 0 0 0 0 86 0 0 8 86 0 0 % L
% Met: 0 0 0 0 0 0 0 0 15 0 0 8 15 0 0 % M
% Asn: 8 0 36 0 0 0 0 0 0 0 15 0 0 0 0 % N
% Pro: 15 8 36 0 15 79 0 0 0 22 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 8 0 % R
% Ser: 0 0 8 0 0 0 0 0 0 8 0 0 0 8 0 % S
% Thr: 15 0 15 8 58 0 0 65 0 0 0 0 0 86 8 % T
% Val: 58 0 0 0 0 0 86 0 0 0 79 0 0 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 22 0 0 0 72 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _