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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF3
All Species:
44.55
Human Site:
T521
Identified Species:
75.38
UniProt:
O43395
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43395
NP_004689.1
683
77529
T521
A
N
A
A
R
K
L
T
A
E
Q
R
K
V
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101105
683
77496
T521
A
N
A
A
R
K
L
T
A
E
Q
R
K
V
K
Dog
Lupus familis
XP_860581
685
77562
T523
A
N
A
A
R
K
L
T
A
E
Q
R
K
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q922U1
683
77436
T521
A
N
A
A
R
K
L
T
A
E
Q
R
K
V
K
Rat
Rattus norvegicus
NP_001102029
637
72177
A498
Q
D
P
T
K
V
E
A
H
V
R
A
Q
M
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509322
682
76176
T524
A
N
A
A
R
K
L
T
K
E
E
R
K
A
K
Chicken
Gallus gallus
Q5ZJ85
684
77367
T522
A
N
A
A
R
K
L
T
A
E
Q
R
K
A
K
Frog
Xenopus laevis
NP_001085273
679
76844
T519
A
N
A
A
R
K
L
T
A
E
Q
R
K
E
K
Zebra Danio
Brachydanio rerio
NP_991311
700
78843
T541
A
N
A
A
R
K
L
T
A
E
Q
R
K
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649156
598
67364
T441
A
N
N
A
R
K
L
T
S
E
Q
K
S
E
K
Honey Bee
Apis mellifera
XP_392148
633
72356
T475
A
N
A
A
R
R
L
T
A
D
Q
R
R
E
K
Nematode Worm
Caenorhab. elegans
NP_499300
621
71178
T457
L
N
A
E
R
K
L
T
E
D
Q
K
R
A
K
Sea Urchin
Strong. purpuratus
XP_780513
572
64792
T433
E
D
T
S
T
G
V
T
V
N
V
Y
R
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03338
469
55852
T335
N
M
N
V
E
K
P
T
V
Y
H
C
K
V
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.8
98.6
N.A.
99.5
90.7
N.A.
66.1
94.4
86.3
71.5
N.A.
48.3
52.2
35.8
49.6
Protein Similarity:
100
N.A.
100
98.8
N.A.
99.7
91.9
N.A.
78.9
97.9
93.5
83.8
N.A.
62.9
68.5
55.4
62.5
P-Site Identity:
100
N.A.
100
100
N.A.
100
0
N.A.
80
93.3
93.3
93.3
N.A.
66.6
73.3
53.3
13.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
33.3
N.A.
86.6
93.3
93.3
93.3
N.A.
80
93.3
73.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
72
0
72
72
0
0
0
8
58
0
0
8
0
22
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
15
0
0
0
0
0
0
0
15
0
0
0
0
0
% D
% Glu:
8
0
0
8
8
0
8
0
8
65
8
0
0
29
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
79
0
0
8
0
0
15
65
0
79
% K
% Leu:
8
0
0
0
0
0
79
0
0
0
0
0
0
0
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
79
15
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
72
0
8
0
0
% Q
% Arg:
0
0
0
0
79
8
0
0
0
0
8
65
22
0
0
% R
% Ser:
0
0
0
8
0
0
0
0
8
0
0
0
8
0
0
% S
% Thr:
0
0
8
8
8
0
0
93
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
0
8
8
0
15
8
8
0
0
43
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _