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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR7A2
All Species:
18.48
Human Site:
Y225
Identified Species:
50.83
UniProt:
O43488
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43488
NP_003680.2
359
39589
Y225
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
Chimpanzee
Pan troglodytes
XP_001163068
359
39556
F225
F
G
L
R
F
Y
A
F
N
P
L
A
G
G
L
Rhesus Macaque
Macaca mulatta
XP_001092177
359
39643
Y225
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
Dog
Lupus familis
XP_535385
371
40597
Y237
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG76
367
40580
Y233
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
Rat
Rattus norvegicus
Q8CG45
367
40657
Y233
F
G
L
R
F
Y
A
Y
N
P
L
A
G
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417628
326
36606
T215
D
K
D
T
R
Q
P
T
G
R
F
F
G
N
D
Frog
Xenopus laevis
NP_001089776
333
37843
K216
G
R
Y
K
Y
E
D
K
D
K
E
Q
A
T
C
Zebra Danio
Brachydanio rerio
NP_001002369
323
36462
A212
D
K
D
G
A
Q
P
A
G
R
F
F
G
N
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
95.5
84
N.A.
86.3
86.3
N.A.
N.A.
66.5
67.6
62.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98
97.7
89.4
N.A.
90.1
89.9
N.A.
N.A.
77.9
77.1
75.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
100
N.A.
100
100
N.A.
N.A.
6.6
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
67
12
0
0
0
67
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% C
% Asp:
23
0
23
0
0
0
12
0
12
0
0
0
0
0
12
% D
% Glu:
0
0
0
0
0
12
0
0
0
0
12
0
0
0
0
% E
% Phe:
67
0
0
0
67
0
0
12
0
0
23
23
0
0
0
% F
% Gly:
12
67
0
12
0
0
0
0
23
0
0
0
89
67
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
23
0
12
0
0
0
12
0
12
0
0
0
0
0
% K
% Leu:
0
0
67
0
0
0
0
0
0
0
67
0
0
0
67
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
67
0
0
0
0
23
12
% N
% Pro:
0
0
0
0
0
0
23
0
0
67
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
23
0
0
0
0
0
12
0
0
0
% Q
% Arg:
0
12
0
67
12
0
0
0
0
23
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
12
0
0
0
12
0
0
0
0
0
12
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
12
67
0
56
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _