KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPB41L2
All Species:
13.64
Human Site:
S647
Identified Species:
33.33
UniProt:
O43491
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43491
NP_001422.1
1005
112588
S647
D
I
L
K
H
Q
A
S
I
S
E
L
K
R
N
Chimpanzee
Pan troglodytes
XP_518738
1057
118386
S647
D
I
L
K
H
Q
A
S
I
S
E
L
K
R
N
Rhesus Macaque
Macaca mulatta
XP_001104857
1245
138660
S887
D
I
L
K
H
Q
A
S
I
S
E
L
K
R
N
Dog
Lupus familis
XP_851612
993
109230
S634
D
I
L
R
H
Q
A
S
I
S
E
L
K
R
N
Cat
Felis silvestris
Mouse
Mus musculus
O70318
988
109815
K635
Q
A
S
I
S
E
L
K
R
N
F
M
A
S
T
Rat
Rattus norvegicus
Q9WTP0
879
98224
L560
K
A
S
E
R
A
G
L
R
E
G
S
E
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505707
703
78909
L384
Q
G
S
S
H
E
T
L
I
V
V
E
E
K
Q
Chicken
Gallus gallus
XP_001232113
843
95195
H524
L
Q
T
Q
G
S
S
H
E
T
L
D
I
V
E
Frog
Xenopus laevis
P11434
801
89411
R482
T
E
S
I
P
K
H
R
F
L
S
L
G
S
T
Zebra Danio
Brachydanio rerio
O57457
619
70690
N300
T
F
F
R
M
P
E
N
E
S
N
S
L
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.9
78.5
81.9
N.A.
82.8
42.7
N.A.
58.3
65.2
43.3
21.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
94.9
79.1
87.5
N.A.
88.9
57.2
N.A.
63
72.7
57.8
36.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
0
0
N.A.
13.3
0
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
20
13.3
N.A.
33.3
20
13.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
0
0
0
10
40
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
10
0
10
0
20
10
0
20
10
40
10
20
10
10
% E
% Phe:
0
10
10
0
0
0
0
0
10
0
10
0
0
0
0
% F
% Gly:
0
10
0
0
10
0
10
0
0
0
10
0
10
0
0
% G
% His:
0
0
0
0
50
0
10
10
0
0
0
0
0
0
0
% H
% Ile:
0
40
0
20
0
0
0
0
50
0
0
0
10
0
0
% I
% Lys:
10
0
0
30
0
10
0
10
0
0
0
0
40
10
10
% K
% Leu:
10
0
40
0
0
0
10
20
0
10
10
50
10
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
10
10
0
0
0
40
% N
% Pro:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
20
10
0
10
0
40
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
20
10
0
0
10
20
0
0
0
0
40
10
% R
% Ser:
0
0
40
10
10
10
10
40
0
50
10
20
0
20
0
% S
% Thr:
20
0
10
0
0
0
10
0
0
10
0
0
0
10
20
% T
% Val:
0
0
0
0
0
0
0
0
0
10
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _