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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FOXO3
All Species:
16.36
Human Site:
S497
Identified Species:
36
UniProt:
O43524
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43524
NP_001446.1
673
71277
S497
D
P
L
M
S
Q
A
S
T
A
V
S
A
Q
N
Chimpanzee
Pan troglodytes
XP_522749
829
87557
M651
S
P
P
H
N
D
I
M
T
P
V
D
P
G
V
Rhesus Macaque
Macaca mulatta
XP_001093593
672
71242
S496
D
P
L
M
S
Q
A
S
T
A
V
S
A
Q
N
Dog
Lupus familis
XP_539075
494
52999
T319
P
L
M
S
Q
A
S
T
A
V
S
A
Q
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9R1E0
652
69484
V477
H
N
D
I
M
S
P
V
D
P
G
V
A
Q
P
Rat
Rattus norvegicus
NP_001099865
672
71179
S496
D
P
L
M
S
Q
A
S
T
A
V
S
A
Q
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511165
628
67175
S453
S
A
Q
N
P
R
R
S
V
M
L
R
S
D
P
Chicken
Gallus gallus
Q90964
451
48838
L276
Y
W
P
M
S
P
F
L
S
L
H
H
P
R
A
Frog
Xenopus laevis
Q6EUW1
657
70366
S482
D
P
L
M
S
Q
A
S
T
A
V
T
A
Q
N
Zebra Danio
Brachydanio rerio
NP_571160
651
69843
A476
S
D
P
L
I
S
Q
A
S
A
A
V
T
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95V55
613
67394
Q437
V
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
S
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40
99.5
71
N.A.
45
94.5
N.A.
67.4
22.2
70.7
58.9
N.A.
29.5
N.A.
N.A.
N.A.
Protein Similarity:
100
52.4
99.6
72.3
N.A.
61
96.5
N.A.
74.7
34.4
80.8
71.7
N.A.
42.6
N.A.
N.A.
N.A.
P-Site Identity:
100
20
100
0
N.A.
13.3
100
N.A.
6.6
13.3
93.3
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
100
33.3
N.A.
20
100
N.A.
26.6
26.6
100
26.6
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
37
10
10
46
10
10
46
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
37
10
10
0
0
10
0
0
10
0
0
10
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% G
% His:
10
0
0
10
0
0
0
0
0
0
10
10
0
0
0
% H
% Ile:
0
0
0
10
10
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
37
10
0
0
0
10
0
10
10
0
10
0
0
% L
% Met:
0
0
10
46
10
0
0
10
0
10
0
0
0
0
0
% M
% Asn:
0
10
0
10
10
0
0
0
0
0
0
0
0
10
37
% N
% Pro:
10
46
28
0
10
10
10
0
0
19
0
0
19
0
19
% P
% Gln:
0
10
19
10
19
46
19
10
10
10
10
10
10
46
10
% Q
% Arg:
0
0
0
0
0
10
10
0
0
0
0
10
0
10
0
% R
% Ser:
28
0
0
10
46
19
10
46
19
0
10
28
10
19
10
% S
% Thr:
0
0
0
0
0
0
0
10
46
0
0
10
10
0
0
% T
% Val:
10
0
0
0
0
0
0
10
10
10
46
19
0
0
10
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _