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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS3
All Species:
24.85
Human Site:
S375
Identified Species:
49.7
UniProt:
O43559
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43559
NP_006644.1
492
54462
S375
T
P
L
Q
K
P
T
S
T
R
A
A
I
R
S
Chimpanzee
Pan troglodytes
XP_001174236
492
54439
S375
T
P
L
Q
K
P
T
S
T
R
A
A
I
R
S
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
S375
T
P
L
Q
K
P
T
S
T
R
A
A
I
R
S
Dog
Lupus familis
XP_538915
496
54822
S379
T
P
L
Q
K
P
T
S
A
R
A
A
L
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q91WJ0
492
53957
S375
T
P
L
Q
K
P
T
S
T
R
A
S
A
R
S
Rat
Rattus norvegicus
Q52RG8
492
54329
S375
T
P
L
Q
K
P
T
S
T
R
A
S
A
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
D415
V
N
N
P
C
A
R
D
R
A
W
E
R
D
A
Chicken
Gallus gallus
XP_418044
464
51898
S346
P
L
Q
N
Y
M
N
S
E
S
T
A
L
H
G
Frog
Xenopus laevis
NP_001085015
517
58232
R403
Q
N
Y
M
N
A
E
R
T
T
A
C
G
G
Y
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
Q370
G
F
H
S
L
D
P
Q
H
N
Y
V
N
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
L352
T
R
H
C
Y
A
N
L
E
S
N
E
I
E
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
S553
P
E
L
R
T
P
R
S
T
S
S
K
G
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
93.5
N.A.
86.1
88
N.A.
55.6
57.3
56.4
44.3
N.A.
N.A.
21.9
N.A.
24.1
Protein Similarity:
100
99.5
99.5
94.9
N.A.
89.6
90.8
N.A.
63.7
67.4
67.1
58.9
N.A.
N.A.
36.9
N.A.
37.9
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
0
13.3
13.3
0
N.A.
N.A.
13.3
N.A.
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
6.6
20
13.3
0
N.A.
N.A.
20
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
25
0
0
9
9
59
42
17
0
9
% A
% Cys:
0
0
0
9
9
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
9
0
0
0
0
0
9
0
% D
% Glu:
0
9
0
0
0
0
9
0
17
0
0
17
0
9
9
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
0
17
9
9
% G
% His:
0
0
17
0
0
0
0
0
9
0
0
0
0
9
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
34
0
0
% I
% Lys:
0
0
0
0
50
0
0
0
0
0
0
9
0
0
0
% K
% Leu:
0
9
59
0
9
0
0
9
0
0
0
0
17
0
0
% L
% Met:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
17
9
9
9
0
17
0
0
9
9
0
9
0
9
% N
% Pro:
17
50
0
9
0
59
9
0
0
0
0
0
0
0
0
% P
% Gln:
9
0
9
50
0
0
0
9
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
9
0
0
17
9
9
50
0
0
9
50
0
% R
% Ser:
0
0
0
9
0
0
0
67
0
25
9
17
0
9
50
% S
% Thr:
59
0
0
0
9
0
50
0
59
9
9
0
0
9
9
% T
% Val:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
9
0
17
0
0
0
0
0
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _