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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS3
All Species:
17.58
Human Site:
S437
Identified Species:
35.15
UniProt:
O43559
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43559
NP_006644.1
492
54462
S437
P
K
G
P
Q
N
P
S
S
P
Q
A
P
M
P
Chimpanzee
Pan troglodytes
XP_001174236
492
54439
L437
P
K
G
P
Q
N
P
L
S
P
Q
A
P
M
P
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
S437
P
K
G
P
Q
N
P
S
S
P
Q
A
P
M
P
Dog
Lupus familis
XP_538915
496
54822
S441
P
K
G
P
Q
N
P
S
A
P
R
A
P
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q91WJ0
492
53957
S437
P
K
G
P
Q
N
P
S
V
S
G
A
P
G
P
Rat
Rattus norvegicus
Q52RG8
492
54329
S437
P
K
G
P
Q
N
P
S
V
S
G
A
P
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
W497
L
Q
S
P
G
V
P
W
A
L
G
P
A
P
T
Chicken
Gallus gallus
XP_418044
464
51898
S409
H
K
G
H
P
N
V
S
A
S
R
A
R
P
A
Frog
Xenopus laevis
NP_001085015
517
58232
P462
E
G
K
A
G
P
I
P
Q
I
T
C
T
L
A
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
P430
D
S
S
G
P
H
T
P
K
T
P
T
T
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
P409
M
N
L
P
L
D
G
P
S
N
S
T
A
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
V659
T
T
P
P
K
T
P
V
S
P
P
T
E
I
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
93.5
N.A.
86.1
88
N.A.
55.6
57.3
56.4
44.3
N.A.
N.A.
21.9
N.A.
24.1
Protein Similarity:
100
99.5
99.5
94.9
N.A.
89.6
90.8
N.A.
63.7
67.4
67.1
58.9
N.A.
N.A.
36.9
N.A.
37.9
P-Site Identity:
100
93.3
100
80
N.A.
73.3
73.3
N.A.
13.3
33.3
0
0
N.A.
N.A.
20
N.A.
26.6
P-Site Similarity:
100
93.3
100
93.3
N.A.
73.3
73.3
N.A.
26.6
46.6
6.6
6.6
N.A.
N.A.
26.6
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
25
0
0
59
17
9
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% D
% Glu:
9
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
59
9
17
0
9
0
0
0
25
0
0
17
0
% G
% His:
9
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
9
0
0
0
9
0
% I
% Lys:
0
59
9
0
9
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
0
9
0
9
0
0
9
0
9
0
0
0
9
9
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
25
0
% M
% Asn:
0
9
0
0
0
59
0
0
0
9
0
0
0
0
0
% N
% Pro:
50
0
9
75
17
9
67
25
0
42
17
9
50
25
59
% P
% Gln:
0
9
0
0
50
0
0
0
9
0
25
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
17
0
9
0
0
% R
% Ser:
0
9
17
0
0
0
0
50
42
25
9
0
0
9
0
% S
% Thr:
9
9
0
0
0
9
9
0
0
9
9
25
17
0
9
% T
% Val:
0
0
0
0
0
9
9
9
17
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _