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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRS3 All Species: 18.79
Human Site: T445 Identified Species: 37.58
UniProt: O43559 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43559 NP_006644.1 492 54462 T445 S P Q A P M P T T H P A R S S
Chimpanzee Pan troglodytes XP_001174236 492 54439 T445 S P Q A P M P T T H P A R S S
Rhesus Macaque Macaca mulatta XP_001084538 492 54416 T445 S P Q A P M P T T H P A R S S
Dog Lupus familis XP_538915 496 54822 T449 A P R A P A P T T H P T R S S
Cat Felis silvestris
Mouse Mus musculus Q91WJ0 492 53957 T445 V S G A P G P T P H P V R S S
Rat Rattus norvegicus Q52RG8 492 54329 T445 V S G A P G P T P H P A R S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518131 552 59439 A505 A L G P A P T A P T P A R R V
Chicken Gallus gallus XP_418044 464 51898 A417 A S R A R P A A S H E A H R T
Frog Xenopus laevis NP_001085015 517 58232 P470 Q I T C T L A P N H Q V R R A
Zebra Danio Brachydanio rerio XP_001923962 485 53928 P438 K T P T T P L P A T P T R R T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122793 483 53108 P417 S N S T A S P P E S P N K L Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781457 717 77816 P667 S P P T E I V P T V P G S K N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99.1 93.5 N.A. 86.1 88 N.A. 55.6 57.3 56.4 44.3 N.A. N.A. 21.9 N.A. 24.1
Protein Similarity: 100 99.5 99.5 94.9 N.A. 89.6 90.8 N.A. 63.7 67.4 67.1 58.9 N.A. N.A. 36.9 N.A. 37.9
P-Site Identity: 100 100 100 73.3 N.A. 60 66.6 N.A. 20 20 13.3 13.3 N.A. N.A. 20 N.A. 26.6
P-Site Similarity: 100 100 100 86.6 N.A. 60 66.6 N.A. 26.6 46.6 26.6 20 N.A. N.A. 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 0 0 59 17 9 17 17 9 0 0 50 0 0 9 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 0 9 0 9 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 25 0 0 17 0 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 67 0 0 9 0 0 % H
% Ile: 0 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 0 0 0 0 0 0 0 0 0 0 9 9 0 % K
% Leu: 0 9 0 0 0 9 9 0 0 0 0 0 0 9 0 % L
% Met: 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 9 0 0 0 0 0 0 9 0 0 9 0 0 9 % N
% Pro: 0 42 17 9 50 25 59 34 25 0 84 0 0 0 0 % P
% Gln: 9 0 25 0 0 0 0 0 0 0 9 0 0 0 9 % Q
% Arg: 0 0 17 0 9 0 0 0 0 0 0 0 75 34 0 % R
% Ser: 42 25 9 0 0 9 0 0 9 9 0 0 9 50 50 % S
% Thr: 0 9 9 25 17 0 9 50 42 17 0 17 0 0 17 % T
% Val: 17 0 0 0 0 0 9 0 0 9 0 17 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _