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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRS3
All Species:
42.12
Human Site:
Y455
Identified Species:
84.24
UniProt:
O43559
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43559
NP_006644.1
492
54462
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Chimpanzee
Pan troglodytes
XP_001174236
492
54439
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Rhesus Macaque
Macaca mulatta
XP_001084538
492
54416
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Dog
Lupus familis
XP_538915
496
54822
Y459
P
T
R
S
S
D
S
Y
A
V
I
D
L
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q91WJ0
492
53957
Y455
P
V
R
S
S
D
S
Y
A
V
I
D
L
K
K
Rat
Rattus norvegicus
Q52RG8
492
54329
Y455
P
A
R
S
S
D
S
Y
A
V
I
D
L
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518131
552
59439
Y515
P
A
R
R
V
D
S
Y
A
V
I
D
L
K
K
Chicken
Gallus gallus
XP_418044
464
51898
Y427
E
A
H
R
T
D
S
Y
A
V
I
D
L
K
K
Frog
Xenopus laevis
NP_001085015
517
58232
Y480
Q
V
R
R
A
D
S
Y
A
V
I
D
L
K
K
Zebra Danio
Brachydanio rerio
XP_001923962
485
53928
Y448
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122793
483
53108
Y427
P
N
K
L
Q
K
G
Y
A
T
I
D
F
N
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781457
717
77816
Y677
P
G
S
K
N
D
I
Y
A
R
I
D
I
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.1
93.5
N.A.
86.1
88
N.A.
55.6
57.3
56.4
44.3
N.A.
N.A.
21.9
N.A.
24.1
Protein Similarity:
100
99.5
99.5
94.9
N.A.
89.6
90.8
N.A.
63.7
67.4
67.1
58.9
N.A.
N.A.
36.9
N.A.
37.9
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
86.6
73.3
73.3
46.6
N.A.
N.A.
40
N.A.
46.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
86.6
80
80
80
N.A.
N.A.
46.6
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
0
0
9
0
0
0
100
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
84
0
0
0
0
0
100
0
0
0
% D
% Glu:
9
0
0
0
0
9
0
0
0
0
0
0
0
17
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% F
% Gly:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% G
% His:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
100
0
17
0
0
% I
% Lys:
0
0
9
9
0
9
0
0
0
0
0
0
0
75
92
% K
% Leu:
0
0
0
9
0
0
9
0
0
0
0
0
75
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
9
0
0
0
0
0
0
0
0
9
0
% N
% Pro:
84
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
75
34
0
0
0
0
0
9
0
0
0
0
9
% R
% Ser:
0
0
9
50
50
0
75
0
0
0
0
0
0
0
0
% S
% Thr:
0
17
0
0
17
0
0
0
0
9
0
0
0
0
0
% T
% Val:
0
17
0
0
9
0
0
0
0
84
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _