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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: XPOT All Species: 32.42
Human Site: S266 Identified Species: 54.87
UniProt: O43592 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43592 NP_009166.2 962 109964 S266 D K M K L V E S L C Q V L Q S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116910 962 109962 S266 D K M K L V E S L C Q V L Q S
Dog Lupus familis XP_531658 962 110054 S266 D K M K L V E S L C Q V L Q S
Cat Felis silvestris
Mouse Mus musculus Q9CRT8 963 109715 S267 D K M K L V E S L C Q V L Q T
Rat Rattus norvegicus NP_001101572 728 83466 F113 A Q V F A L L F V T E Y L T K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508666 962 109919 S266 D K T K L V E S L C R V L Q S
Chicken Gallus gallus XP_416065 962 109808 S266 D K T K L V E S L C Q V L Q S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5SPJ8 961 109329 S266 D K T K L V E S L C Q V L Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_501320 950 105658 T266 K K V G L T L T I M T V L R S
Sea Urchin Strong. purpuratus XP_786292 944 107893 S266 A K T E L V E S V T K V L Q D
Poplar Tree Populus trichocarpa XP_002304132 994 112620 I279 D H Q S K L A I L Q N L Q I N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177400 988 111444 L275 D P Q S K L P L L Q T L Q I S
Baker's Yeast Sacchar. cerevisiae P33418 1100 126801 L296 A F L N M I N L T N E L T Y Y
Red Bread Mold Neurospora crassa Q7RWV9 1026 114793 G290 L I S F L N L G G I I T E L L
Conservation
Percent
Protein Identity: 100 N.A. 99.9 99.2 N.A. 95 68.6 N.A. 94.9 93.8 N.A. 78.4 N.A. N.A. N.A. 25.5 50.8
Protein Similarity: 100 N.A. 100 99.9 N.A. 98.2 72.2 N.A. 98.2 98.1 N.A. 89.9 N.A. N.A. N.A. 47.1 70.2
P-Site Identity: 100 N.A. 100 100 N.A. 93.3 6.6 N.A. 86.6 93.3 N.A. 93.3 N.A. N.A. N.A. 33.3 53.3
P-Site Similarity: 100 N.A. 100 100 N.A. 100 40 N.A. 93.3 93.3 N.A. 93.3 N.A. N.A. N.A. 60 73.3
Percent
Protein Identity: 28.1 N.A. N.A. 28.5 20.2 25.8
Protein Similarity: 50.4 N.A. N.A. 50.7 42.3 45.4
P-Site Identity: 13.3 N.A. N.A. 20 0 6.6
P-Site Similarity: 33.3 N.A. N.A. 33.3 33.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 50 0 0 0 0 0 % C
% Asp: 65 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 0 0 0 8 0 0 58 0 0 0 15 0 8 0 0 % E
% Phe: 0 8 0 15 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 8 8 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 8 0 8 8 8 8 0 0 15 0 % I
% Lys: 8 65 0 50 15 0 0 0 0 0 8 0 0 0 8 % K
% Leu: 8 0 8 0 72 22 22 15 65 0 0 22 72 8 8 % L
% Met: 0 0 29 0 8 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 8 0 0 8 8 0 0 0 8 % N
% Pro: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 15 0 0 0 0 0 0 15 43 0 15 58 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % R
% Ser: 0 0 8 15 0 0 0 58 0 0 0 0 0 0 58 % S
% Thr: 0 0 29 0 0 8 0 8 8 15 15 8 8 8 8 % T
% Val: 0 0 15 0 0 58 0 0 15 0 0 65 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _