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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPRY1
All Species:
13.33
Human Site:
S312
Identified Species:
29.33
UniProt:
O43609
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43609
NP_005832.1
319
35122
S312
C
K
L
E
S
C
P
S
R
G
Q
G
K
P
S
Chimpanzee
Pan troglodytes
XP_517428
319
35122
S312
C
K
L
E
S
C
P
S
R
G
Q
G
K
P
S
Rhesus Macaque
Macaca mulatta
XP_001104216
319
35059
S312
C
K
L
E
S
C
P
S
R
G
Q
D
K
P
S
Dog
Lupus familis
XP_540958
319
34873
S312
C
K
L
E
S
C
P
S
R
G
Q
G
K
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QXV9
313
33986
Rat
Rattus norvegicus
NP_001012046
314
34517
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510585
619
67001
P612
C
K
V
P
S
V
P
P
R
N
F
E
K
P
T
Chicken
Gallus gallus
Q9PTL2
313
34398
Frog
Xenopus laevis
NP_001153153
319
35322
Zebra Danio
Brachydanio rerio
NP_001116072
292
31610
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44783
589
62370
A509
Q
G
I
G
G
G
G
A
G
S
G
G
G
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.7
97.8
N.A.
83.3
51.4
N.A.
28.7
51.7
77.4
54.2
N.A.
21.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
99
98.4
N.A.
89.6
66.4
N.A.
38.6
66.4
84.3
64.2
N.A.
33.1
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
0
0
N.A.
46.6
0
0
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
0
0
N.A.
60
0
0
0
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% A
% Cys:
46
0
0
0
0
37
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% D
% Glu:
0
0
0
37
0
0
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
10
0
10
10
10
10
0
10
37
10
37
10
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
46
0
0
0
0
0
0
0
0
0
0
46
0
0
% K
% Leu:
0
0
37
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
46
10
0
0
0
0
0
46
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
37
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
46
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
46
0
0
37
0
10
0
0
0
0
37
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
10
0
0
10
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _