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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPRY1 All Species: 13.64
Human Site: S50 Identified Species: 30
UniProt: O43609 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43609 NP_005832.1 319 35122 S50 Q I K A I R G S N E Y T E G P
Chimpanzee Pan troglodytes XP_517428 319 35122 S50 Q I K A I R G S N E Y T E G P
Rhesus Macaque Macaca mulatta XP_001104216 319 35059 S50 Q I K A I R G S N E Y T E G P
Dog Lupus familis XP_540958 319 34873 S50 Q I K A I R G S N E Y T E G P
Cat Felis silvestris
Mouse Mus musculus Q9QXV9 313 33986 R48 L D Q I K A I R G S N E Y T E
Rat Rattus norvegicus NP_001012046 314 34517 I49 S L D Q I R A I R N T N E Y T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510585 619 67001 R353 L D Q I R A I R N T N E Y T E
Chicken Gallus gallus Q9PTL2 313 34398 A48 L S L D Q I R A I R N T N E Y
Frog Xenopus laevis NP_001153153 319 35322 R50 Q I K A L R S R N E Y T E G P
Zebra Danio Brachydanio rerio NP_001116072 292 31610 N27 Q I K A I R S N N E Y T E G P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O44783 589 62370 D90 P A S P D F D D Y Q I H H L T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.7 97.8 N.A. 83.3 51.4 N.A. 28.7 51.7 77.4 54.2 N.A. 21.8 N.A. N.A. N.A.
Protein Similarity: 100 99.6 99 98.4 N.A. 89.6 66.4 N.A. 38.6 66.4 84.3 64.2 N.A. 33.1 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 0 20 N.A. 6.6 6.6 80 86.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 6.6 26.6 N.A. 13.3 13.3 86.6 93.3 N.A. 6.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 55 0 19 10 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 19 10 10 10 0 10 10 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 55 0 19 64 10 19 % E
% Phe: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 37 0 10 0 0 0 0 55 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % H
% Ile: 0 55 0 19 55 10 19 10 10 0 10 0 0 0 0 % I
% Lys: 0 0 55 0 10 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 28 10 10 0 10 0 0 0 0 0 0 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 64 10 28 10 10 0 0 % N
% Pro: 10 0 0 10 0 0 0 0 0 0 0 0 0 0 55 % P
% Gln: 55 0 19 10 10 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 64 10 28 10 10 0 0 0 0 0 % R
% Ser: 10 10 10 0 0 0 19 37 0 10 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 10 64 0 19 19 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 55 0 19 10 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _