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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPRY3
All Species:
13.94
Human Site:
S274
Identified Species:
30.67
UniProt:
O43610
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43610
NP_005831.1
288
31222
S274
N
T
V
C
R
K
I
S
S
G
S
A
P
F
P
Chimpanzee
Pan troglodytes
XP_527058
322
34921
A309
N
S
V
I
C
K
A
A
S
G
D
A
K
T
S
Rhesus Macaque
Macaca mulatta
XP_001099973
288
31231
S274
N
T
V
C
R
K
I
S
S
G
S
A
P
F
P
Dog
Lupus familis
XP_549391
288
31273
S274
N
T
V
C
R
K
I
S
S
G
S
A
P
F
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9QXV8
315
34605
N297
G
C
R
C
K
N
S
N
T
V
C
C
K
V
P
Rat
Rattus norvegicus
NP_001102533
281
30348
S267
N
T
V
C
R
K
M
S
S
G
G
S
P
C
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510585
619
67001
C485
H
A
Y
R
C
E
D
C
G
K
C
K
C
K
E
Chicken
Gallus gallus
Q9PTL2
313
34398
K300
H
S
N
T
V
C
C
K
V
P
S
V
P
P
R
Frog
Xenopus laevis
NP_001082238
314
35083
N296
G
C
Q
C
K
R
S
N
T
V
C
L
K
V
P
Zebra Danio
Brachydanio rerio
XP_001343190
275
30099
T262
V
C
R
K
I
S
A
T
N
P
A
P
F
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44783
589
62370
G505
G
C
R
C
Q
G
I
G
G
G
G
A
G
S
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.2
99.6
97.9
N.A.
40.6
81.5
N.A.
28.2
40.2
36.3
53.4
N.A.
24.6
N.A.
N.A.
N.A.
Protein Similarity:
100
55.2
100
98.2
N.A.
55.8
88.1
N.A.
35.8
54.9
54.4
65.2
N.A.
32.4
N.A.
N.A.
N.A.
P-Site Identity:
100
40
100
100
N.A.
13.3
73.3
N.A.
0
13.3
13.3
0
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
100
100
N.A.
33.3
86.6
N.A.
13.3
26.6
40
20
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
19
10
0
0
10
46
0
0
0
% A
% Cys:
0
37
0
64
19
10
10
10
0
0
28
10
10
10
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
28
0
% F
% Gly:
28
0
0
0
0
10
0
10
19
55
19
0
10
0
10
% G
% His:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
10
10
0
37
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
19
46
0
10
0
10
0
10
28
10
10
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
46
0
10
0
0
10
0
19
10
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
19
0
10
46
10
55
% P
% Gln:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
28
10
37
10
0
0
0
0
0
0
0
10
10
% R
% Ser:
0
19
0
0
0
10
19
37
46
0
37
10
0
10
10
% S
% Thr:
0
37
0
10
0
0
0
10
19
0
0
0
0
10
0
% T
% Val:
10
0
46
0
10
0
0
0
10
19
0
10
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _