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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPRY3
All Species:
13.33
Human Site:
Y252
Identified Species:
29.33
UniProt:
O43610
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43610
NP_005831.1
288
31222
Y252
L
H
L
C
Q
Q
G
Y
D
S
L
R
R
P
G
Chimpanzee
Pan troglodytes
XP_527058
322
34921
G287
C
V
K
L
A
Q
R
G
Y
D
R
L
R
R
P
Rhesus Macaque
Macaca mulatta
XP_001099973
288
31231
Y252
L
H
L
C
Q
R
G
Y
D
S
L
R
R
P
G
Dog
Lupus familis
XP_549391
288
31273
Y252
L
H
L
C
Q
Q
G
Y
D
S
L
R
R
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9QXV8
315
34605
C275
C
Y
L
P
A
K
G
C
L
K
L
C
Q
G
C
Rat
Rattus norvegicus
NP_001102533
281
30348
Y245
L
R
L
C
Q
R
G
Y
D
S
L
R
R
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510585
619
67001
K463
V
Q
P
K
S
E
L
K
P
S
E
L
K
P
L
Chicken
Gallus gallus
Q9PTL2
313
34398
Q278
K
G
C
L
K
L
C
Q
G
C
Y
D
R
V
N
Frog
Xenopus laevis
NP_001082238
314
35083
C274
C
Y
L
P
A
K
G
C
L
K
L
C
Q
G
C
Zebra Danio
Brachydanio rerio
XP_001343190
275
30099
D240
T
L
C
Q
R
G
Y
D
R
A
T
R
P
G
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44783
589
62370
C483
F
Y
W
P
M
R
G
C
M
K
L
C
E
K
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.2
99.6
97.9
N.A.
40.6
81.5
N.A.
28.2
40.2
36.3
53.4
N.A.
24.6
N.A.
N.A.
N.A.
Protein Similarity:
100
55.2
100
98.2
N.A.
55.8
88.1
N.A.
35.8
54.9
54.4
65.2
N.A.
32.4
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
93.3
100
N.A.
20
86.6
N.A.
13.3
6.6
20
6.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
40
93.3
N.A.
33.3
13.3
40
20
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
28
0
0
0
0
10
0
0
0
0
0
% A
% Cys:
28
0
19
37
0
0
10
28
0
10
0
28
0
0
37
% C
% Asp:
0
0
0
0
0
0
0
10
37
10
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
10
0
10
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
10
64
10
10
0
0
0
0
28
37
% G
% His:
0
28
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
10
10
10
19
0
10
0
28
0
0
10
10
0
% K
% Leu:
37
10
55
19
0
10
10
0
19
0
64
19
0
0
10
% L
% Met:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
0
10
28
0
0
0
0
10
0
0
0
10
46
10
% P
% Gln:
0
10
0
10
37
28
0
10
0
0
0
0
19
0
0
% Q
% Arg:
0
10
0
0
10
28
10
0
10
0
10
46
55
10
0
% R
% Ser:
0
0
0
0
10
0
0
0
0
46
0
0
0
0
0
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% T
% Val:
10
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
28
0
0
0
0
10
37
10
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _