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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WBSCR22 All Species: 47.58
Human Site: T273 Identified Species: 80.51
UniProt: O43709 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43709 NP_059998.2 281 31880 T273 V R P D T Q Y T G R K R K P R
Chimpanzee Pan troglodytes XP_001146333 288 32424 T280 V R P D T Q Y T G R K R K P R
Rhesus Macaque Macaca mulatta XP_001115175 244 26972 G237 F T N E R E G G A F E G R G I
Dog Lupus familis XP_536843 284 32044 T276 V R P D T Q Y T G R K R K P R
Cat Felis silvestris
Mouse Mus musculus Q9CY21 281 31568 T273 V R P D T Q Y T G R K R K P R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034421 282 31481 T274 V R A D T K Y T G R K R R P Q
Frog Xenopus laevis NP_001085369 282 31627 S274 V R A D T K F S G R K R R P H
Zebra Danio Brachydanio rerio NP_001076348 282 31663 T274 V R A D T K Y T G R H R K P K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649762 276 31107 T268 T R P D T K Y T A R K R S G K
Honey Bee Apis mellifera XP_623810 275 31197 T267 V R E D S K Y T G R K R C G K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786791 283 31707 T274 V R P D S K Y T G R K R S G K
Poplar Tree Populus trichocarpa XP_002300071 289 32108 T281 V P P D T R Y T G R K R K A R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_200538 289 32368 T281 V P A D S K F T S R K R R T R
Baker's Yeast Sacchar. cerevisiae P25627 275 30724 T267 V A K D S K F T G R K R R H R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94 84.6 82.7 N.A. 79.7 N.A. N.A. N.A. 69.8 66.3 65.9 N.A. 59.7 58.7 N.A. 59.3
Protein Similarity: 100 94.4 84.6 91.9 N.A. 91.4 N.A. N.A. N.A. 83.3 85.1 83.6 N.A. 75 77.5 N.A. 77.3
P-Site Identity: 100 100 0 100 N.A. 100 N.A. N.A. N.A. 73.3 60 73.3 N.A. 60 60 N.A. 66.6
P-Site Similarity: 100 100 26.6 100 N.A. 100 N.A. N.A. N.A. 93.3 86.6 86.6 N.A. 73.3 80 N.A. 86.6
Percent
Protein Identity: 54.3 N.A. N.A. 52.6 48 N.A.
Protein Similarity: 69.9 N.A. N.A. 68.8 68.3 N.A.
P-Site Identity: 80 N.A. N.A. 46.6 53.3 N.A.
P-Site Similarity: 86.6 N.A. N.A. 73.3 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 29 0 0 0 0 0 15 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 0 93 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 8 0 8 0 0 0 0 8 0 0 0 0 % E
% Phe: 8 0 0 0 0 0 22 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 8 79 0 0 8 0 29 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 8 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 8 0 0 58 0 0 0 0 86 0 43 0 29 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 15 50 0 0 0 0 0 0 0 0 0 0 50 0 % P
% Gln: 0 0 0 0 0 29 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 72 0 0 8 8 0 0 0 93 0 93 36 0 50 % R
% Ser: 0 0 0 0 29 0 0 8 8 0 0 0 15 0 0 % S
% Thr: 8 8 0 0 65 0 0 86 0 0 0 0 0 8 0 % T
% Val: 86 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 72 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _