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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WBSCR22 All Species: 24.55
Human Site: T37 Identified Species: 41.54
UniProt: O43709 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43709 NP_059998.2 281 31880 T37 S R M I D I Q T R M A G R A L
Chimpanzee Pan troglodytes XP_001146333 288 32424 T37 S R M I D I Q T R M A G R A L
Rhesus Macaque Macaca mulatta XP_001115175 244 26972 R24 F Y D E K E A R K Y V R N S R
Dog Lupus familis XP_536843 284 32044 T37 S R M I D V Q T K M A G R A L
Cat Felis silvestris
Mouse Mus musculus Q9CY21 281 31568 T37 S R M I D I Q T K M T E R A L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034421 282 31481 A37 S R V A E I Q A Q M A A R A V
Frog Xenopus laevis NP_001085369 282 31627 T37 S R M I E I Q T Q M S E R A V
Zebra Danio Brachydanio rerio NP_001076348 282 31663 T37 S R M I E I Q T Q M S E R A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649762 276 31107 A37 I E I Q V E M A E R A L E L L
Honey Bee Apis mellifera XP_623810 275 31197 C37 I D I Q E Q M C R R A L E L L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786791 283 31707 T37 R M I E I Q M T M S E R A I E
Poplar Tree Populus trichocarpa XP_002300071 289 32108 S37 I D I Q A R L S E R A L E L L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_200538 289 32368 S37 V E I Q A K L S E R A L E L L
Baker's Yeast Sacchar. cerevisiae P25627 275 30724 E41 K M T L R A L E L L N L Q P C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94 84.6 82.7 N.A. 79.7 N.A. N.A. N.A. 69.8 66.3 65.9 N.A. 59.7 58.7 N.A. 59.3
Protein Similarity: 100 94.4 84.6 91.9 N.A. 91.4 N.A. N.A. N.A. 83.3 85.1 83.6 N.A. 75 77.5 N.A. 77.3
P-Site Identity: 100 100 0 86.6 N.A. 80 N.A. N.A. N.A. 53.3 66.6 66.6 N.A. 13.3 20 N.A. 6.6
P-Site Similarity: 100 100 13.3 100 N.A. 86.6 N.A. N.A. N.A. 80 93.3 93.3 N.A. 20 33.3 N.A. 13.3
Percent
Protein Identity: 54.3 N.A. N.A. 52.6 48 N.A.
Protein Similarity: 69.9 N.A. N.A. 68.8 68.3 N.A.
P-Site Identity: 13.3 N.A. N.A. 13.3 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 15 8 8 15 0 0 58 8 8 50 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % C
% Asp: 0 15 8 0 29 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 15 0 15 29 15 0 8 22 0 8 22 29 0 8 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 22 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 22 0 36 43 8 43 0 0 0 0 0 0 0 8 0 % I
% Lys: 8 0 0 0 8 8 0 0 22 0 0 0 0 0 0 % K
% Leu: 0 0 0 8 0 0 22 0 8 8 0 36 0 29 58 % L
% Met: 0 15 43 0 0 0 22 0 8 50 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 29 0 15 50 0 22 0 0 0 8 0 0 % Q
% Arg: 8 50 0 0 8 8 0 8 22 29 0 15 50 0 8 % R
% Ser: 50 0 0 0 0 0 0 15 0 8 15 0 0 8 0 % S
% Thr: 0 0 8 0 0 0 0 50 0 0 8 0 0 0 0 % T
% Val: 8 0 8 0 8 8 0 0 0 0 8 0 0 0 22 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _