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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WBSCR22 All Species: 30.61
Human Site: Y191 Identified Species: 51.79
UniProt: O43709 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43709 NP_059998.2 281 31880 Y191 S G G M V V D Y P N S A K A K
Chimpanzee Pan troglodytes XP_001146333 288 32424 Y198 S G G M V V D Y P N S A K A K
Rhesus Macaque Macaca mulatta XP_001115175 244 26972 Q162 R G S R A V L Q L Y P E N S E
Dog Lupus familis XP_536843 284 32044 F191 T G G V V V D F P N S A K A K
Cat Felis silvestris
Mouse Mus musculus Q9CY21 281 31568 F191 T G G V V V D F P N S A K A K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034421 282 31481 Y191 T G G M V I D Y P N S A K A K
Frog Xenopus laevis NP_001085369 282 31627 Y191 T G G M V V D Y P N S A K A K
Zebra Danio Brachydanio rerio NP_001076348 282 31663 Y191 T G G M V V D Y P N S S K A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649762 276 31107 Y189 Y G G L V V D Y P N S A K A K
Honey Bee Apis mellifera XP_623810 275 31197 F188 Y G G V V V D F P N S T K A K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786791 283 31707 F190 T G G L V V D F P N S T R A K
Poplar Tree Populus trichocarpa XP_002300071 289 32108 Y189 A G G V V I D Y P H S A K S R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_200538 289 32368 Y189 G G G L V V D Y P H S T K K R
Baker's Yeast Sacchar. cerevisiae P25627 275 30724 D186 S G G L V V D D P E S K K N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94 84.6 82.7 N.A. 79.7 N.A. N.A. N.A. 69.8 66.3 65.9 N.A. 59.7 58.7 N.A. 59.3
Protein Similarity: 100 94.4 84.6 91.9 N.A. 91.4 N.A. N.A. N.A. 83.3 85.1 83.6 N.A. 75 77.5 N.A. 77.3
P-Site Identity: 100 100 13.3 80 N.A. 80 N.A. N.A. N.A. 86.6 93.3 86.6 N.A. 86.6 73.3 N.A. 66.6
P-Site Similarity: 100 100 26.6 100 N.A. 100 N.A. N.A. N.A. 100 100 100 N.A. 93.3 86.6 N.A. 93.3
Percent
Protein Identity: 54.3 N.A. N.A. 52.6 48 N.A.
Protein Similarity: 69.9 N.A. N.A. 68.8 68.3 N.A.
P-Site Identity: 60 N.A. N.A. 60 66.6 N.A.
P-Site Similarity: 100 N.A. N.A. 80 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 8 0 0 0 0 0 0 58 0 72 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 93 8 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 % F
% Gly: 8 100 93 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 8 86 8 79 % K
% Leu: 0 0 0 29 0 0 8 0 8 0 0 0 0 0 0 % L
% Met: 0 0 0 36 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 72 0 0 8 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 93 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 8 0 0 0 0 0 0 0 0 8 0 15 % R
% Ser: 22 0 8 0 0 0 0 0 0 0 93 8 0 15 0 % S
% Thr: 43 0 0 0 0 0 0 0 0 0 0 22 0 0 0 % T
% Val: 0 0 0 29 93 86 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 0 0 0 0 0 0 58 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _