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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLX2
All Species:
23.94
Human Site:
S140
Identified Species:
43.89
UniProt:
O43763
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43763
NP_057254.1
284
30251
S140
T
A
A
L
S
P
F
S
G
T
R
R
I
G
H
Chimpanzee
Pan troglodytes
XP_001161223
284
30206
S140
T
A
A
L
S
P
F
S
G
T
R
R
I
G
H
Rhesus Macaque
Macaca mulatta
XP_001110250
284
30204
S140
T
A
A
L
S
P
F
S
G
T
R
R
I
G
H
Dog
Lupus familis
XP_855075
284
30159
S140
T
A
A
L
S
P
F
S
G
T
R
R
I
G
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61663
284
30342
S140
T
A
A
L
S
P
F
S
G
T
R
R
I
G
H
Rat
Rattus norvegicus
O88181
384
41445
D212
H
G
T
K
E
E
G
D
R
E
I
T
S
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511680
344
37696
T193
M
E
S
N
R
R
Y
T
K
D
R
F
T
G
H
Chicken
Gallus gallus
O93367
297
32351
T155
A
A
A
L
T
P
F
T
V
T
R
R
I
G
H
Frog
Xenopus laevis
Q8JJ64
306
34004
G161
E
G
K
K
D
D
S
G
E
D
W
K
K
R
E
Zebra Danio
Brachydanio rerio
Q504H8
297
33069
I153
D
G
K
K
E
G
G
I
D
D
W
K
K
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VEI9
592
62591
D451
I
E
E
D
D
G
T
D
G
P
S
D
S
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
K32
R
R
T
S
H
L
I
K
D
I
L
D
L
P
T
Sea Urchin
Strong. purpuratus
Q26656
405
44721
G236
S
E
H
R
R
N
N
G
H
E
E
D
D
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
91.1
N.A.
92.9
25.5
N.A.
46.7
57.5
27.1
22.5
N.A.
21.4
N.A.
26
25.6
Protein Similarity:
100
100
99.3
93.6
N.A.
95
33.8
N.A.
55.2
65.6
37.9
33
N.A.
28.2
N.A.
36.6
36.5
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
20
73.3
0
0
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
40
86.6
6.6
6.6
N.A.
6.6
N.A.
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
47
47
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
8
16
8
0
16
16
24
0
24
8
8
16
% D
% Glu:
8
24
8
0
16
8
0
0
8
16
8
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
47
0
0
0
0
8
0
0
0
% F
% Gly:
0
24
0
0
0
16
16
16
47
0
0
0
0
54
0
% G
% His:
8
0
8
0
8
0
0
0
8
0
0
0
0
0
54
% H
% Ile:
8
0
0
0
0
0
8
8
0
8
8
0
47
0
0
% I
% Lys:
0
0
16
24
0
0
0
8
8
0
0
16
16
0
0
% K
% Leu:
0
0
0
47
0
8
0
0
0
0
8
0
8
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
47
0
0
0
8
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
8
0
8
16
8
0
0
8
0
54
47
0
8
8
% R
% Ser:
8
0
8
8
39
0
8
39
0
0
8
0
16
24
8
% S
% Thr:
39
0
16
0
8
0
8
16
0
47
0
8
8
0
8
% T
% Val:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _