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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
20.91
Human Site:
S133
Identified Species:
32.86
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
S133
T
V
K
S
N
S
S
S
K
A
P
K
V
V
P
Chimpanzee
Pan troglodytes
XP_524527
588
65774
S133
T
V
K
S
N
S
S
S
K
A
P
K
V
V
P
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
S133
T
V
K
S
N
S
S
S
K
A
P
K
V
V
P
Dog
Lupus familis
XP_537131
637
71340
A183
A
V
K
P
S
N
S
A
K
S
S
K
V
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
S132
A
V
K
C
N
L
S
S
R
P
S
K
V
L
P
Rat
Rattus norvegicus
Q4V8A3
586
65492
S132
T
V
K
C
S
L
S
S
R
P
S
K
V
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
A115
Q
Y
L
Q
K
L
T
A
F
E
Q
H
E
I
A
Chicken
Gallus gallus
Q5ZIU3
526
59419
K115
F
L
G
P
N
A
K
K
R
Q
G
V
I
G
G
Frog
Xenopus laevis
NP_001088793
567
63329
A113
S
K
S
S
E
S
S
A
K
S
S
K
A
T
Y
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
K124
K
S
S
E
S
S
T
K
V
T
K
L
G
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
H201
G
Q
Q
K
C
E
L
H
E
K
P
K
V
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
S385
G
S
Q
G
G
H
N
S
N
S
G
S
N
S
G
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
S117
S
D
G
S
K
N
G
S
A
K
G
R
A
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
F68
P
L
Y
Y
G
P
E
F
A
S
G
L
V
P
N
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
S245
R
L
S
A
Y
P
P
S
T
S
P
P
L
Q
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
53.3
N.A.
53.3
53.3
N.A.
0
6.6
33.3
13.3
N.A.
20
N.A.
6.6
20
P-Site Similarity:
100
100
100
80
N.A.
66.6
73.3
N.A.
20
33.3
53.3
26.6
N.A.
40
N.A.
26.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
7
0
7
0
20
14
20
0
0
14
0
7
% A
% Cys:
0
0
0
14
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
7
7
7
7
0
7
7
0
0
7
0
0
% E
% Phe:
7
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% F
% Gly:
14
0
14
7
14
0
7
0
0
0
27
0
7
7
14
% G
% His:
0
0
0
0
0
7
0
7
0
0
0
7
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% I
% Lys:
7
7
40
7
14
0
7
14
34
14
7
54
0
0
0
% K
% Leu:
0
20
7
0
0
20
7
0
0
0
0
14
7
27
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
34
14
7
0
7
0
0
0
7
0
7
% N
% Pro:
7
0
0
14
0
14
7
0
0
14
34
7
0
7
60
% P
% Gln:
7
7
14
7
0
0
0
0
0
7
7
0
0
7
0
% Q
% Arg:
7
0
0
0
0
0
0
0
20
0
0
7
0
0
0
% R
% Ser:
14
14
20
34
20
34
47
54
0
34
27
7
0
14
0
% S
% Thr:
27
0
0
0
0
0
14
0
7
7
0
0
0
7
0
% T
% Val:
0
40
0
0
0
0
0
0
7
0
0
7
54
27
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
7
7
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _