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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPOP All Species: 30.61
Human Site: S330 Identified Species: 56.11
UniProt: O43791 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43791 NP_001007227.1 374 42132 S330 D F I N Y H A S D V L E T S G
Chimpanzee Pan troglodytes XP_001168292 392 44160 L330 D F I N Y S G L L A E G A H A
Rhesus Macaque Macaca mulatta XP_001094028 392 44244 L330 D F I N Y F H L L L Q L T M N
Dog Lupus familis XP_865058 415 46627 S371 D F I N Y H A S D V L E T S G
Cat Felis silvestris
Mouse Mus musculus Q2M2N2 392 44655 V330 D F I N R C S V L R Q L G C K
Rat Rattus norvegicus NP_001127919 392 44725 V330 D F I N R C S V L R Q L G C K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509972 374 42178 T330 D F I N S Q A T D I M E T A G
Chicken Gallus gallus XP_423281 374 42132 S330 D F I N Y H A S D V M E T S G
Frog Xenopus laevis Q7ZX06 374 42136 S330 D F I N Y H A S D V M E T S G
Zebra Danio Brachydanio rerio Q7T330 374 42116 S330 D F I N Y H A S D V M E T S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFP2 829 89649 T785 D F I N T H A T D V M E T S G
Honey Bee Apis mellifera XP_395294 396 44485 T352 D F I N T H A T D V M D T A G
Nematode Worm Caenorhab. elegans P34568 451 51044 N401 N F I N V N A N E V M D T E G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.1 95.4 90.1 N.A. 79.5 79.5 N.A. 84.7 99.7 98.6 97.3 N.A. 36.6 76.5 54.7 N.A.
Protein Similarity: 100 95.4 95.4 90.1 N.A. 88.5 88.5 N.A. 93 100 99.4 98.9 N.A. 41.1 85.8 68.7 N.A.
P-Site Identity: 100 33.3 40 100 N.A. 26.6 26.6 N.A. 60 93.3 93.3 93.3 N.A. 80 66.6 46.6 N.A.
P-Site Similarity: 100 33.3 46.6 100 N.A. 33.3 33.3 N.A. 86.6 100 100 100 N.A. 93.3 93.3 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 70 0 0 8 0 0 8 16 8 % A
% Cys: 0 0 0 0 0 16 0 0 0 0 0 0 0 16 0 % C
% Asp: 93 0 0 0 0 0 0 0 62 0 0 16 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 8 54 0 8 0 % E
% Phe: 0 100 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 8 16 0 70 % G
% His: 0 0 0 0 0 54 8 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 100 0 0 0 0 0 0 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 16 % K
% Leu: 0 0 0 0 0 0 0 16 31 8 16 24 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 54 0 0 8 0 % M
% Asn: 8 0 0 100 0 8 0 8 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 24 0 0 0 0 % Q
% Arg: 0 0 0 0 16 0 0 0 0 16 0 0 0 0 0 % R
% Ser: 0 0 0 0 8 8 16 39 0 0 0 0 0 47 0 % S
% Thr: 0 0 0 0 16 0 0 24 0 0 0 0 77 0 0 % T
% Val: 0 0 0 0 8 0 0 16 0 62 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 54 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _