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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH3B
All Species:
38.18
Human Site:
S178
Identified Species:
64.62
UniProt:
O43837
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43837
NP_008830.2
385
42184
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Chimpanzee
Pan troglodytes
XP_001157460
385
42195
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Rhesus Macaque
Macaca mulatta
XP_001114288
385
42236
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Dog
Lupus familis
XP_534367
385
42314
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Cat
Felis silvestris
Mouse
Mus musculus
P70404
393
42767
S181
Y
S
S
L
E
H
E
S
V
A
G
V
V
E
S
Rat
Rattus norvegicus
Q68FX0
385
42335
S178
Y
S
S
L
E
H
E
S
A
R
G
V
I
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026558
385
42312
S177
Y
S
S
L
E
H
E
S
A
K
G
V
I
E
C
Frog
Xenopus laevis
NP_001085395
376
41736
S173
Y
S
S
L
E
H
E
S
V
S
G
V
I
A
C
Zebra Danio
Brachydanio rerio
NP_001002157
382
41838
S178
Y
S
S
L
E
H
E
S
V
A
G
V
V
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VWH4
377
40826
I176
Y
S
G
I
E
H
E
I
V
D
G
V
V
Q
S
Honey Bee
Apis mellifera
XP_624511
374
40935
S171
Y
S
A
L
E
H
E
S
V
K
G
V
V
E
C
Nematode Worm
Caenorhab. elegans
Q93353
379
41534
L175
Y
S
S
L
E
H
E
L
V
P
G
V
I
E
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93032
367
39572
V161
Y
A
G
L
E
H
E
V
V
P
G
V
V
E
S
Baker's Yeast
Sacchar. cerevisiae
P28834
360
39306
M165
V
V
E
S
L
K
V
M
T
R
P
K
T
E
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.6
96
N.A.
48.5
94
N.A.
N.A.
84.1
79.4
78.6
N.A.
38.9
57.9
57.1
N.A.
Protein Similarity:
100
99.7
98.9
97.4
N.A.
64.3
96.6
N.A.
N.A.
90.6
87.2
85.7
N.A.
60.7
72.9
71.4
N.A.
P-Site Identity:
100
100
100
100
N.A.
73.3
100
N.A.
N.A.
93.3
80
80
N.A.
46.6
73.3
80
N.A.
P-Site Similarity:
100
100
100
100
N.A.
80
100
N.A.
N.A.
100
80
86.6
N.A.
66.6
93.3
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
45.9
45.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
0
0
0
43
15
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
72
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
8
0
93
0
93
0
0
0
0
0
0
86
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
15
0
0
0
0
0
0
0
93
0
0
0
0
% G
% His:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
8
0
0
0
0
58
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
15
0
8
0
0
0
% K
% Leu:
0
0
0
86
8
0
0
8
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
15
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
43
0
0
0
0
8
% R
% Ser:
0
86
72
8
0
0
0
72
0
8
0
0
0
0
22
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% T
% Val:
8
8
0
0
0
0
8
8
50
0
0
93
36
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _