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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDH3B
All Species:
41.21
Human Site:
T153
Identified Species:
69.74
UniProt:
O43837
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43837
NP_008830.2
385
42184
T153
K
S
L
P
G
Y
M
T
R
H
N
N
L
D
L
Chimpanzee
Pan troglodytes
XP_001157460
385
42195
T153
K
S
L
P
G
Y
M
T
R
H
N
N
L
D
L
Rhesus Macaque
Macaca mulatta
XP_001114288
385
42236
T153
K
S
L
P
G
Y
M
T
R
H
N
N
L
D
L
Dog
Lupus familis
XP_534367
385
42314
T153
K
S
L
P
G
Y
K
T
R
H
N
N
L
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P70404
393
42767
T156
K
S
L
P
G
V
V
T
R
H
K
D
I
D
I
Rat
Rattus norvegicus
Q68FX0
385
42335
T153
K
S
L
P
G
Y
K
T
R
H
N
N
L
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026558
385
42312
T152
K
S
L
P
G
Y
K
T
R
H
N
N
L
D
L
Frog
Xenopus laevis
NP_001085395
376
41736
T148
K
S
L
P
G
Y
K
T
R
H
N
N
L
D
L
Zebra Danio
Brachydanio rerio
NP_001002157
382
41838
T153
K
S
L
P
G
Y
S
T
R
H
N
N
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VWH4
377
40826
T151
R
S
L
E
G
Y
K
T
L
Y
D
D
V
D
V
Honey Bee
Apis mellifera
XP_624511
374
40935
C146
K
S
L
P
G
V
K
C
R
H
K
N
V
D
C
Nematode Worm
Caenorhab. elegans
Q93353
379
41534
R150
T
L
D
G
I
K
T
R
H
G
K
Q
L
D
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93032
367
39572
S136
F
N
L
P
G
L
A
S
R
H
E
N
V
D
I
Baker's Yeast
Sacchar. cerevisiae
P28834
360
39306
R140
D
I
D
L
I
V
I
R
E
N
T
E
G
E
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.6
96
N.A.
48.5
94
N.A.
N.A.
84.1
79.4
78.6
N.A.
38.9
57.9
57.1
N.A.
Protein Similarity:
100
99.7
98.9
97.4
N.A.
64.3
96.6
N.A.
N.A.
90.6
87.2
85.7
N.A.
60.7
72.9
71.4
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
60
93.3
N.A.
N.A.
93.3
93.3
93.3
N.A.
40
60
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
93.3
N.A.
N.A.
93.3
93.3
93.3
N.A.
80
66.6
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
45.9
45.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% C
% Asp:
8
0
15
0
0
0
0
0
0
0
8
15
0
93
0
% D
% Glu:
0
0
0
8
0
0
0
0
8
0
8
8
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% F
% Gly:
0
0
0
8
86
0
0
0
0
8
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
79
0
0
0
0
0
% H
% Ile:
0
8
0
0
15
0
8
0
0
0
0
0
8
0
15
% I
% Lys:
72
0
0
0
0
8
43
0
0
0
22
0
0
0
0
% K
% Leu:
0
8
86
8
0
8
0
0
8
0
0
0
65
0
58
% L
% Met:
0
0
0
0
0
0
22
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
8
58
72
0
0
0
% N
% Pro:
0
0
0
79
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
15
79
0
0
0
0
0
0
% R
% Ser:
0
79
0
0
0
0
8
8
0
0
0
0
0
0
0
% S
% Thr:
8
0
0
0
0
0
8
72
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
22
8
0
0
0
0
0
22
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
65
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _