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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NRD1 All Species: 13.03
Human Site: T59 Identified Species: 23.89
UniProt: O43847 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43847 NP_001095132.1 1150 131572 T59 G R N K A K S T C S C P D L Q
Chimpanzee Pan troglodytes XP_001140946 1151 131624 T59 G R N K A K S T C S C P D L Q
Rhesus Macaque Macaca mulatta XP_001105075 1237 141727 R77 L Q N T P C V R H K R A R C P
Dog Lupus familis XP_859649 1159 132371 T60 G R N K A K S T C S C P D L Q
Cat Felis silvestris
Mouse Mus musculus Q8BHG1 1161 132873 K56 M P G R N K A K S T C S C P D
Rat Rattus norvegicus P47245 1161 132957 K56 M P G R N K A K S T C S C P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509651 859 96644
Chicken Gallus gallus NP_001026455 1158 132212 S55 P G R N K A T S N Y G C P E L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_694205 1091 124552 S51 G D P Q I I K S P S D P K Q Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P22817 990 113666
Honey Bee Apis mellifera XP_624437 1061 122950 S55 E N G I Q E S S I C V S K E S
Nematode Worm Caenorhab. elegans Q10040 856 98243
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q06010 1027 117560 T40 V R R F K P F T C L S R Y Y T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 84.3 94.1 N.A. 92.4 92.3 N.A. 47.4 76 N.A. 68.3 N.A. 29.1 38.7 25.1 N.A.
Protein Similarity: 100 99.8 85.9 96.7 N.A. 95.2 95.1 N.A. 54.6 85.7 N.A. 81.9 N.A. 47.8 58.8 42.5 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 13.3 13.3 N.A. 0 0 N.A. 20 N.A. 0 6.6 0 N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 33.3 33.3 N.A. 0 13.3 N.A. 33.3 N.A. 0 20 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 24 8 16 0 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 31 8 39 8 16 8 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 0 8 0 24 0 16 % D
% Glu: 8 0 0 0 0 8 0 0 0 0 0 0 0 16 0 % E
% Phe: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 31 8 24 0 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 8 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 24 16 39 8 16 0 8 0 0 16 0 0 % K
% Leu: 8 0 0 0 0 0 0 0 0 8 0 0 0 24 8 % L
% Met: 16 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 31 8 16 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 8 16 8 0 8 8 0 0 8 0 0 31 8 16 8 % P
% Gln: 0 8 0 8 8 0 0 0 0 0 0 0 0 8 24 % Q
% Arg: 0 31 16 16 0 0 0 8 0 0 8 8 8 0 0 % R
% Ser: 0 0 0 0 0 0 31 24 16 31 8 24 0 0 8 % S
% Thr: 0 0 0 8 0 0 8 31 0 16 0 0 0 0 8 % T
% Val: 8 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 8 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _