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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CREB3 All Species: 11.21
Human Site: S278 Identified Species: 24.67
UniProt: O43889 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43889 NP_006359.3 395 43917 S278 Y S S D T R G S L P A E H G V
Chimpanzee Pan troglodytes XP_524059 461 49123 K346 I S P F G P N K T E S P G D F
Rhesus Macaque Macaca mulatta XP_001085696 372 41757 S255 Y S S D T R G S L P A E H G V
Dog Lupus familis XP_854750 411 45117 Y293 L L I V P A M Y S S D T R G S
Cat Felis silvestris
Mouse Mus musculus Q61817 404 45093 S289 Y S S D A R G S V P A E Y V V
Rat Rattus norvegicus Q5FVM5 470 50844 V343 S P F T A N K V D S P G D F I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515078 497 52525 Q338 Y P L G T G V Q Q Q D F R G G
Chicken Gallus gallus XP_424990 441 48727 P315 Y S F G S R G P Q P E F R V L
Frog Xenopus laevis A2VD01 525 57606 Y406 F T Q N L D M Y S S S S K T I
Zebra Danio Brachydanio rerio Q1LYG4 428 48314 K313 L K P F T D T K V S Q H G D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790412 454 50364 S332 N P F N G D S S S L G S S A V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.8 89.3 57.9 N.A. 66.3 29.5 N.A. 37 36.2 24 29.2 N.A. N.A. N.A. N.A. 28.8
Protein Similarity: 100 44 91.1 67.8 N.A. 75 45.7 N.A. 49.9 51 39.2 46.7 N.A. N.A. N.A. N.A. 44.7
P-Site Identity: 100 6.6 100 6.6 N.A. 73.3 0 N.A. 20 33.3 0 6.6 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 13.3 100 6.6 N.A. 86.6 6.6 N.A. 20 46.6 33.3 13.3 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 19 10 0 0 0 0 28 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 28 0 28 0 0 10 0 19 0 10 19 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 10 10 28 0 0 0 % E
% Phe: 10 0 28 19 0 0 0 0 0 0 0 19 0 10 19 % F
% Gly: 0 0 0 19 19 10 37 0 0 0 10 10 19 37 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 19 0 0 % H
% Ile: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 19 % I
% Lys: 0 10 0 0 0 0 10 19 0 0 0 0 10 0 0 % K
% Leu: 19 10 10 0 10 0 0 0 19 10 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 0 19 0 10 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 28 19 0 10 10 0 10 0 37 10 10 0 0 0 % P
% Gln: 0 0 10 0 0 0 0 10 19 10 10 0 0 0 0 % Q
% Arg: 0 0 0 0 0 37 0 0 0 0 0 0 28 0 0 % R
% Ser: 10 46 28 0 10 0 10 37 28 37 19 19 10 0 10 % S
% Thr: 0 10 0 10 37 0 10 0 10 0 0 10 0 10 0 % T
% Val: 0 0 0 10 0 0 10 10 19 0 0 0 0 19 37 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 46 0 0 0 0 0 0 19 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _