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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLL1
All Species:
43.33
Human Site:
Y539
Identified Species:
73.33
UniProt:
O43897
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43897
NP_036596.3
1013
114709
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Chimpanzee
Pan troglodytes
XP_001150703
1013
114731
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Rhesus Macaque
Macaca mulatta
XP_001101883
1013
114718
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Dog
Lupus familis
XP_539791
1045
118180
Y571
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Cat
Felis silvestris
Mouse
Mus musculus
Q62381
1013
114514
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Rat
Rattus norvegicus
NP_001099551
1013
114567
Y539
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509196
1014
114574
Y540
L
I
G
H
F
C
G
Y
D
K
P
E
D
I
R
Chicken
Gallus gallus
Q9DER7
1008
114873
Y535
L
I
G
H
F
C
G
Y
D
K
P
E
D
I
R
Frog
Xenopus laevis
Q8JI28
1007
114347
Y534
L
I
G
H
F
C
G
Y
D
K
P
E
D
I
R
Zebra Danio
Brachydanio rerio
O57460
1022
115518
Y548
L
I
G
R
F
C
G
Y
D
K
P
E
D
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25723
1067
121762
D556
L
I
G
R
F
C
G
D
K
L
P
P
N
I
K
Honey Bee
Apis mellifera
XP_393866
1225
138704
Y735
L
I
G
V
Y
C
G
Y
K
I
P
P
D
I
K
Nematode Worm
Caenorhab. elegans
Q20176
951
107516
H511
A
T
D
K
N
I
C
H
H
Y
C
V
N
T
V
Sea Urchin
Strong. purpuratus
P98069
639
71875
H201
V
V
V
H
E
L
G
H
V
V
G
F
W
H
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.1
89.9
N.A.
93.5
93.5
N.A.
89.2
88.1
85.2
81.1
N.A.
41.5
45
42.5
38.3
Protein Similarity:
100
100
99.6
92.6
N.A.
96.4
96.3
N.A.
94.2
93.9
92.9
90.9
N.A.
59
60
59.2
48.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
100
N.A.
60
60
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
100
N.A.
73.3
73.3
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
86
8
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
8
72
0
0
0
79
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
72
0
0
8
% E
% Phe:
0
0
0
0
79
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
86
0
0
0
93
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
29
0
0
0
15
8
0
0
0
0
8
0
% H
% Ile:
0
86
0
0
0
8
0
0
0
8
0
0
0
86
0
% I
% Lys:
0
0
0
8
0
0
0
0
15
72
0
0
0
0
15
% K
% Leu:
86
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
15
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
86
15
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
58
0
0
0
0
0
0
0
0
0
0
72
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
8
8
8
8
0
0
0
0
8
8
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
8
0
0
79
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _