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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ORC4L All Species: 29.39
Human Site: S261 Identified Species: 58.79
UniProt: O43929 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43929 NP_002543.2 436 50377 S261 Q Y L S E D R S V Q E V L Q K
Chimpanzee Pan troglodytes XP_001159181 436 50421 S261 Q Y L S E D R S V Q E V L R K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533348 436 50555 S261 Q C L M E D R S V R E V L Q K
Cat Felis silvestris
Mouse Mus musculus O88708 433 49963 T258 H C L S E D S T V L E V L Q K
Rat Rattus norvegicus Q6P9Z8 434 50086 T259 H C L S E D S T V L E V L Q K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511605 435 50275 S260 K R L A E D K S V R E I L Q R
Chicken Gallus gallus XP_422152 495 56654 T320 Q L L T E D K T V Q D I L Q N
Frog Xenopus laevis O93479 432 49392 L259 K S L V E S K L V E D V L Q K
Zebra Danio Brachydanio rerio NP_998348 432 49308 S259 T K L C E D K S V L E V L K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477320 459 51917 Q283 C K V L A T Q Q A R S T L Q A
Honey Bee Apis mellifera XP_625030 451 52162 T280 K S L V S N V T I V N L L K K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P54791 529 60687 H323 P R S N L N R H I R M N F E T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 94.2 N.A. 89.2 88.9 N.A. 82.1 67.2 72 65.5 N.A. 42.7 47 N.A. N.A.
Protein Similarity: 100 99.7 N.A. 97.4 N.A. 94.7 94.9 N.A. 91 76.9 84.8 81.6 N.A. 60.7 66 N.A. N.A.
P-Site Identity: 100 93.3 N.A. 80 N.A. 66.6 66.6 N.A. 53.3 53.3 46.6 53.3 N.A. 13.3 20 N.A. N.A.
P-Site Similarity: 100 100 N.A. 86.6 N.A. 73.3 73.3 N.A. 93.3 86.6 73.3 73.3 N.A. 33.3 60 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 9 0 0 0 9 0 0 0 0 0 9 % A
% Cys: 9 25 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 67 0 0 0 0 17 0 0 0 0 % D
% Glu: 0 0 0 0 75 0 0 0 0 9 59 0 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 17 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 17 0 0 17 0 0 0 % I
% Lys: 25 17 0 0 0 0 34 0 0 0 0 0 0 17 59 % K
% Leu: 0 9 84 9 9 0 0 9 0 25 0 9 92 0 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 0 0 9 0 17 0 0 0 0 9 9 0 0 9 % N
% Pro: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 34 0 0 0 0 0 9 9 0 25 0 0 0 67 0 % Q
% Arg: 0 17 0 0 0 0 34 0 0 34 0 0 0 9 17 % R
% Ser: 0 17 9 34 9 9 17 42 0 0 9 0 0 0 0 % S
% Thr: 9 0 0 9 0 9 0 34 0 0 0 9 0 0 9 % T
% Val: 0 0 9 17 0 0 9 0 75 9 0 59 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _