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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ORC4L All Species: 28.18
Human Site: T149 Identified Species: 56.36
UniProt: O43929 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43929 NP_002543.2 436 50377 T149 A L K K G D R T S S C P V I F
Chimpanzee Pan troglodytes XP_001159181 436 50421 T149 A L K K G D R T S S C P V I F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533348 436 50555 S149 A L K K G D R S S S C P V I F
Cat Felis silvestris
Mouse Mus musculus O88708 433 49963 T146 A L K K G D R T S S C P V I F
Rat Rattus norvegicus Q6P9Z8 434 50086 T147 A L Q K G N R T S S C P V I F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511605 435 50275 A148 A L K R G D R A R S C P V L F
Chicken Gallus gallus XP_422152 495 56654 T208 A L R K G D R T S S C P V L F
Frog Xenopus laevis O93479 432 49392 K147 A L K T G D R K S S C P V L F
Zebra Danio Brachydanio rerio NP_998348 432 49308 S147 A L K K G D K S S S R P V L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477320 459 51917 H138 C L K A G G K H S K S V I F I
Honey Bee Apis mellifera XP_625030 451 52162 K146 C L K S G D K K S S K P V I F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P54791 529 60687 S190 K I L L L L D S T T K T R N E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 94.2 N.A. 89.2 88.9 N.A. 82.1 67.2 72 65.5 N.A. 42.7 47 N.A. N.A.
Protein Similarity: 100 99.7 N.A. 97.4 N.A. 94.7 94.9 N.A. 91 76.9 84.8 81.6 N.A. 60.7 66 N.A. N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 86.6 N.A. 73.3 86.6 80 73.3 N.A. 26.6 66.6 N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 86.6 100 86.6 93.3 N.A. 40 73.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 75 0 0 9 0 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 17 0 0 0 0 0 0 0 0 0 67 0 0 0 0 % C
% Asp: 0 0 0 0 0 75 9 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 84 % F
% Gly: 0 0 0 0 92 9 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 0 9 50 9 % I
% Lys: 9 0 75 59 0 0 25 17 0 9 17 0 0 0 0 % K
% Leu: 0 92 9 9 9 9 0 0 0 0 0 0 0 34 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 84 0 0 0 % P
% Gln: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 9 9 0 0 67 0 9 0 9 0 9 0 0 % R
% Ser: 0 0 0 9 0 0 0 25 84 84 9 0 0 0 0 % S
% Thr: 0 0 0 9 0 0 0 42 9 9 0 9 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 9 84 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _