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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR1B10
All Species:
25.76
Human Site:
T288
Identified Species:
62.96
UniProt:
O60218
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60218
NP_064695.3
316
36021
T288
L
S
D
E
E
M
A
T
I
L
S
F
N
R
N
Chimpanzee
Pan troglodytes
XP_001140450
316
36004
T288
L
S
D
E
E
M
A
T
I
L
S
F
N
R
N
Rhesus Macaque
Macaca mulatta
XP_001100959
316
36201
T288
L
S
D
E
E
M
A
T
I
L
S
F
N
R
N
Dog
Lupus familis
XP_539451
316
35679
T288
L
S
S
V
D
M
T
T
L
L
S
Y
N
R
N
Cat
Felis silvestris
Mouse
Mus musculus
P45377
316
36102
T288
L
S
D
E
E
M
A
T
I
L
S
F
N
R
N
Rat
Rattus norvegicus
P07943
316
35779
T288
L
S
N
E
D
M
A
T
L
L
S
Y
N
R
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512253
316
35845
T288
L
S
K
E
E
M
G
T
I
L
S
F
N
R
N
Chicken
Gallus gallus
Q5ZK84
327
37058
H290
L
T
E
E
E
M
S
H
V
G
S
L
N
K
N
Frog
Xenopus laevis
Q6GMC7
327
37081
L290
L
S
E
E
E
M
Q
L
I
G
A
L
N
K
N
Zebra Danio
Brachydanio rerio
Q6AZW2
324
36744
L287
L
S
D
E
D
M
R
L
I
E
S
F
N
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.1
70.8
N.A.
82.5
70.8
N.A.
73.7
51.6
50.4
52.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98
83.8
N.A.
92.7
83.2
N.A.
85.1
68.8
68.5
68.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
60
N.A.
100
73.3
N.A.
86.6
46.6
53.3
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
80
N.A.
100
100
N.A.
86.6
80
73.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
50
0
0
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
50
0
30
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
20
90
70
0
0
0
0
10
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
60
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
0
20
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
70
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
0
0
0
0
20
0
% K
% Leu:
100
0
0
0
0
0
0
20
20
70
0
20
0
0
0
% L
% Met:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
100
0
100
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
0
0
0
0
0
80
0
% R
% Ser:
0
90
10
0
0
0
10
0
0
0
90
0
0
0
0
% S
% Thr:
0
10
0
0
0
0
10
70
0
0
0
0
0
0
0
% T
% Val:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _