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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUAK1
All Species:
18.18
Human Site:
S445
Identified Species:
30.77
UniProt:
O60285
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60285
NP_055655.1
661
74305
S445
T
G
V
L
L
P
S
S
P
E
A
E
V
P
G
Chimpanzee
Pan troglodytes
XP_001161041
661
74289
S445
T
G
V
L
L
P
S
S
P
E
A
E
V
P
G
Rhesus Macaque
Macaca mulatta
XP_001098986
667
74748
S451
T
G
V
L
L
P
S
S
P
E
A
E
V
P
G
Dog
Lupus familis
XP_538417
666
74288
S450
T
G
V
A
V
P
S
S
P
E
A
D
V
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q641K5
658
73643
S446
T
A
I
P
L
P
S
S
P
E
A
D
M
S
G
Rat
Rattus norvegicus
Q66HE5
630
69934
G424
K
K
A
S
P
S
S
G
E
V
Q
E
G
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508265
661
73136
K445
T
G
G
A
L
P
G
K
A
E
G
D
G
P
G
Chicken
Gallus gallus
Q9IA88
798
88848
S437
N
R
S
I
S
P
S
S
L
L
E
T
T
I
S
Frog
Xenopus laevis
NP_001088596
570
64876
P364
E
K
V
P
T
V
Q
P
A
P
K
K
G
I
L
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
N767
L
P
R
M
A
L
A
N
Q
Q
P
S
V
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649991
1427
153426
E1068
R
K
I
N
A
K
A
E
V
Q
L
D
I
K
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
A611
H
G
G
V
Q
M
R
A
Q
P
T
S
R
Q
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
M305
I
V
Q
E
V
V
N
M
G
F
D
R
N
Q
V
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
H424
F
Q
Q
Q
S
K
S
H
Q
K
S
Q
V
D
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
91.7
N.A.
90.9
55.6
N.A.
84.2
26.1
48.5
23.5
N.A.
24.3
N.A.
22.4
N.A.
Protein Similarity:
100
99.8
98
94.4
N.A.
93.8
68
N.A.
88
42.8
61.4
36.2
N.A.
33.6
N.A.
35.8
N.A.
P-Site Identity:
100
100
100
80
N.A.
60
20
N.A.
46.6
20
6.6
13.3
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
80
20
N.A.
53.3
26.6
13.3
40
N.A.
33.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
26.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.3
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
15
15
0
15
8
15
0
36
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
29
0
8
0
% D
% Glu:
8
0
0
8
0
0
0
8
8
43
8
29
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
43
15
0
0
0
8
8
8
0
8
0
22
0
43
% G
% His:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% H
% Ile:
8
0
15
8
0
0
0
0
0
0
0
0
8
15
0
% I
% Lys:
8
22
0
0
0
15
0
8
0
8
8
8
0
8
0
% K
% Leu:
8
0
0
22
36
8
0
0
8
8
8
0
0
0
8
% L
% Met:
0
0
0
8
0
8
0
8
0
0
0
0
8
0
0
% M
% Asn:
8
0
0
8
0
0
8
8
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
15
8
50
0
8
36
15
8
0
0
50
15
% P
% Gln:
0
8
15
8
8
0
8
0
22
15
8
8
0
15
8
% Q
% Arg:
8
8
8
0
0
0
8
0
0
0
0
8
8
0
0
% R
% Ser:
0
0
8
8
15
8
58
43
0
0
8
15
0
8
8
% S
% Thr:
43
0
0
0
8
0
0
0
0
0
8
8
8
0
0
% T
% Val:
0
8
36
8
15
15
0
0
8
8
0
0
43
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _