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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NUAK1 All Species: 18.18
Human Site: S445 Identified Species: 30.77
UniProt: O60285 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60285 NP_055655.1 661 74305 S445 T G V L L P S S P E A E V P G
Chimpanzee Pan troglodytes XP_001161041 661 74289 S445 T G V L L P S S P E A E V P G
Rhesus Macaque Macaca mulatta XP_001098986 667 74748 S451 T G V L L P S S P E A E V P G
Dog Lupus familis XP_538417 666 74288 S450 T G V A V P S S P E A D V P G
Cat Felis silvestris
Mouse Mus musculus Q641K5 658 73643 S446 T A I P L P S S P E A D M S G
Rat Rattus norvegicus Q66HE5 630 69934 G424 K K A S P S S G E V Q E G P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508265 661 73136 K445 T G G A L P G K A E G D G P G
Chicken Gallus gallus Q9IA88 798 88848 S437 N R S I S P S S L L E T T I S
Frog Xenopus laevis NP_001088596 570 64876 P364 E K V P T V Q P A P K K G I L
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 N767 L P R M A L A N Q Q P S V P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649991 1427 153426 E1068 R K I N A K A E V Q L D I K P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A611 H G G V Q M R A Q P T S R Q A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 M305 I V Q E V V N M G F D R N Q V
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 H424 F Q Q Q S K S H Q K S Q V D H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.9 91.7 N.A. 90.9 55.6 N.A. 84.2 26.1 48.5 23.5 N.A. 24.3 N.A. 22.4 N.A.
Protein Similarity: 100 99.8 98 94.4 N.A. 93.8 68 N.A. 88 42.8 61.4 36.2 N.A. 33.6 N.A. 35.8 N.A.
P-Site Identity: 100 100 100 80 N.A. 60 20 N.A. 46.6 20 6.6 13.3 N.A. 0 N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 80 20 N.A. 53.3 26.6 13.3 40 N.A. 33.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.1 26.7 N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 15 15 0 15 8 15 0 36 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 29 0 8 0 % D
% Glu: 8 0 0 8 0 0 0 8 8 43 8 29 0 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 43 15 0 0 0 8 8 8 0 8 0 22 0 43 % G
% His: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % H
% Ile: 8 0 15 8 0 0 0 0 0 0 0 0 8 15 0 % I
% Lys: 8 22 0 0 0 15 0 8 0 8 8 8 0 8 0 % K
% Leu: 8 0 0 22 36 8 0 0 8 8 8 0 0 0 8 % L
% Met: 0 0 0 8 0 8 0 8 0 0 0 0 8 0 0 % M
% Asn: 8 0 0 8 0 0 8 8 0 0 0 0 8 0 0 % N
% Pro: 0 8 0 15 8 50 0 8 36 15 8 0 0 50 15 % P
% Gln: 0 8 15 8 8 0 8 0 22 15 8 8 0 15 8 % Q
% Arg: 8 8 8 0 0 0 8 0 0 0 0 8 8 0 0 % R
% Ser: 0 0 8 8 15 8 58 43 0 0 8 15 0 8 8 % S
% Thr: 43 0 0 0 8 0 0 0 0 0 8 8 8 0 0 % T
% Val: 0 8 36 8 15 15 0 0 8 8 0 0 43 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _