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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NUAK1 All Species: 17.88
Human Site: S459 Identified Species: 30.26
UniProt: O60285 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60285 NP_055655.1 661 74305 S459 G K L S P K Q S A T M P K K G
Chimpanzee Pan troglodytes XP_001161041 661 74289 S459 G K L S P K Q S A T M P K K G
Rhesus Macaque Macaca mulatta XP_001098986 667 74748 S465 G K L S P K Q S A T M P K K G
Dog Lupus familis XP_538417 666 74288 S464 G K L S P K Q S A T M P K K G
Cat Felis silvestris
Mouse Mus musculus Q641K5 658 73643 S460 G K L S L K Q S A T M P K K G
Rat Rattus norvegicus Q66HE5 630 69934 N438 Q E L R P V S N T P G Q P V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508265 661 73136 A459 G P H G P K Q A A T M P K K G
Chicken Gallus gallus Q9IA88 798 88848 K451 S E E V R Q E K E L E D E I K
Frog Xenopus laevis NP_001088596 570 64876 E378 L K K T P Q R E S G Y Y S S P
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 A781 P G S A R T L A Q T L P Q Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649991 1427 153426 A1082 P R I P E Q G A P P Q P A M R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 P625 A T I S L L Q P P S Y K P S S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 R319 V L E S L R N R T Q N D A T V
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 A438 H E T A K Q H A R R M A S A I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.9 91.7 N.A. 90.9 55.6 N.A. 84.2 26.1 48.5 23.5 N.A. 24.3 N.A. 22.4 N.A.
Protein Similarity: 100 99.8 98 94.4 N.A. 93.8 68 N.A. 88 42.8 61.4 36.2 N.A. 33.6 N.A. 35.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 13.3 N.A. 73.3 0 13.3 13.3 N.A. 6.6 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 26.6 N.A. 80 26.6 40 46.6 N.A. 33.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.1 26.7 N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 15 0 0 0 29 43 0 0 8 15 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % D
% Glu: 0 22 15 0 8 0 8 8 8 0 8 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 43 8 0 8 0 0 8 0 0 8 8 0 0 0 43 % G
% His: 8 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 15 0 0 0 0 0 0 0 0 0 0 8 8 % I
% Lys: 0 43 8 0 8 43 0 8 0 0 0 8 43 43 8 % K
% Leu: 8 8 43 0 22 8 8 0 0 8 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 50 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 8 8 0 0 8 0 0 0 0 % N
% Pro: 15 8 0 8 50 0 0 8 15 15 0 58 15 0 15 % P
% Gln: 8 0 0 0 0 29 50 0 8 8 8 8 8 8 8 % Q
% Arg: 0 8 0 8 15 8 8 8 8 8 0 0 0 0 8 % R
% Ser: 8 0 8 50 0 0 8 36 8 8 0 0 15 15 8 % S
% Thr: 0 8 8 8 0 8 0 0 15 50 0 0 0 8 0 % T
% Val: 8 0 0 8 0 8 0 0 0 0 0 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 15 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _