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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NUAK1 All Species: 17.27
Human Site: S542 Identified Species: 29.23
UniProt: O60285 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60285 NP_055655.1 661 74305 S542 T M D P A L V S P E M P T L E
Chimpanzee Pan troglodytes XP_001161041 661 74289 S542 T M D P A L V S P E M P T L E
Rhesus Macaque Macaca mulatta XP_001098986 667 74748 S548 A M D P A L V S P E M P T L E
Dog Lupus familis XP_538417 666 74288 S547 S T D P A L A S P D V P T L E
Cat Felis silvestris
Mouse Mus musculus Q641K5 658 73643 R543 G T D P A L T R P E M P T L E
Rat Rattus norvegicus Q66HE5 630 69934 G521 F S R T A L E G T A P S T F G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508265 661 73136 S542 G M D S A P V S P D P P A P E
Chicken Gallus gallus Q9IA88 798 88848 A534 Q V M T G S P A T A R M T S A
Frog Xenopus laevis NP_001088596 570 64876 E461 L D C P L N E E N M H G G F L
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 S864 N P Y L Q G A S L K V P G L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649991 1427 153426 V1165 S L S R Q S T V E S E S E G T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 Q708 H R D H A Q Q Q Q Y M N Q L T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 H402 L G L Q S H A H P R E I M N E
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E521 Y P L D V M G E I Y I A L K N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.9 91.7 N.A. 90.9 55.6 N.A. 84.2 26.1 48.5 23.5 N.A. 24.3 N.A. 22.4 N.A.
Protein Similarity: 100 99.8 98 94.4 N.A. 93.8 68 N.A. 88 42.8 61.4 36.2 N.A. 33.6 N.A. 35.8 N.A.
P-Site Identity: 100 100 93.3 66.6 N.A. 73.3 20 N.A. 53.3 6.6 6.6 26.6 N.A. 0 N.A. 26.6 N.A.
P-Site Similarity: 100 100 93.3 86.6 N.A. 73.3 20 N.A. 60 20 6.6 40 N.A. 13.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.1 26.7 N.A.
Protein Similarity: N.A. N.A. N.A. 49.3 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 58 0 22 8 0 15 0 8 8 0 8 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 50 8 0 0 0 0 0 15 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 15 15 8 29 15 0 8 0 58 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % F
% Gly: 15 8 0 0 8 8 8 8 0 0 0 8 15 8 8 % G
% His: 8 0 0 8 0 8 0 8 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 8 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % K
% Leu: 15 8 15 8 8 43 0 0 8 0 0 0 8 50 8 % L
% Met: 0 29 8 0 0 8 0 0 0 8 36 8 8 0 0 % M
% Asn: 8 0 0 0 0 8 0 0 8 0 0 8 0 8 8 % N
% Pro: 0 15 0 43 0 8 8 0 50 0 15 50 0 8 0 % P
% Gln: 8 0 0 8 15 8 8 8 8 0 0 0 8 0 0 % Q
% Arg: 0 8 8 8 0 0 0 8 0 8 8 0 0 0 0 % R
% Ser: 15 8 8 8 8 15 0 43 0 8 0 15 0 8 0 % S
% Thr: 15 15 0 15 0 0 15 0 15 0 0 0 50 0 15 % T
% Val: 0 8 0 0 8 0 29 8 0 0 15 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 8 0 0 0 0 0 0 15 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _