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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUAK1
All Species:
37.27
Human Site:
Y143
Identified Species:
63.08
UniProt:
O60285
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60285
NP_055655.1
661
74305
Y143
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Chimpanzee
Pan troglodytes
XP_001161041
661
74289
Y143
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Rhesus Macaque
Macaca mulatta
XP_001098986
667
74748
Y149
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Dog
Lupus familis
XP_538417
666
74288
Y148
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q641K5
658
73643
Y144
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Rat
Rattus norvegicus
Q66HE5
630
69934
Y144
S
R
G
D
L
Y
D
Y
I
S
E
R
P
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508265
661
73136
Y141
S
K
G
E
L
Y
D
Y
I
S
E
R
R
R
L
Chicken
Gallus gallus
Q9IA88
798
88848
H113
K
N
G
E
M
F
D
H
L
T
S
N
G
H
L
Frog
Xenopus laevis
NP_001088596
570
64876
N84
M
S
S
I
C
H
P
N
I
I
S
V
Y
E
V
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
H146
S
G
G
E
I
F
D
H
L
V
A
H
G
R
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649991
1427
153426
Y158
A
G
G
E
L
Y
D
Y
L
S
E
R
K
V
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Y257
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
K24
L
P
N
Y
K
L
G
K
T
L
G
I
G
S
F
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Y142
A
G
N
E
L
F
D
Y
I
V
Q
R
D
K
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
91.7
N.A.
90.9
55.6
N.A.
84.2
26.1
48.5
23.5
N.A.
24.3
N.A.
22.4
N.A.
Protein Similarity:
100
99.8
98
94.4
N.A.
93.8
68
N.A.
88
42.8
61.4
36.2
N.A.
33.6
N.A.
35.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
80
N.A.
100
26.6
6.6
33.3
N.A.
66.6
N.A.
40
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
100
60
20
66.6
N.A.
86.6
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
26.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.3
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
86
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
79
0
0
0
0
0
0
58
0
0
8
0
% E
% Phe:
0
0
0
0
0
29
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
29
79
0
0
0
8
0
0
0
8
0
29
0
0
% G
% His:
0
0
0
0
0
8
0
15
0
0
0
15
0
8
0
% H
% Ile:
0
0
0
8
8
0
0
0
65
8
0
8
0
0
0
% I
% Lys:
8
43
0
0
8
0
0
8
0
0
0
0
8
8
0
% K
% Leu:
8
0
0
0
65
8
0
0
29
8
0
0
0
0
65
% L
% Met:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
22
% M
% Asn:
0
8
15
0
0
0
0
8
0
0
0
8
0
0
0
% N
% Pro:
0
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
65
43
65
0
% R
% Ser:
65
8
8
0
0
0
0
0
0
58
15
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
22
0
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
58
0
72
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _