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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM3AP All Species: 5.15
Human Site: S493 Identified Species: 11.33
UniProt: O60318 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60318 NP_003897.2 1980 218405 S493 L A R K K G K S L H K D M A I
Chimpanzee Pan troglodytes XP_525497 1981 218320 S493 L A R K K G K S L H K D M A I
Rhesus Macaque Macaca mulatta XP_001118009 1415 157213 H92 A V V H F F D H A S A A L A R
Dog Lupus familis XP_537925 1989 218752 G493 L A R K K G K G L H K D M A I
Cat Felis silvestris
Mouse Mus musculus Q9WUU9 1971 217122 K486 A L A R K K G K G L H K D V V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514089 1519 168947 S195 G T D Q V D H S A A I K E Y S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_689234 2082 230356 Q541 K K K G K L F Q R N E I Q I F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U3V9 1370 158161 P46 L V N F V L R P R R M T C T V
Honey Bee Apis mellifera XP_395462 961 111706
Nematode Worm Caenorhab. elegans NP_501328 1116 129063
Sea Urchin Strong. purpuratus XP_795787 1945 218422 P526 P K R E K P P P P P A Y S G M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 69.1 83.7 N.A. 78.4 N.A. N.A. 53.8 N.A. N.A. 42.2 N.A. 21.3 20.6 21.3 25.4
Protein Similarity: 100 99.6 70.1 89.4 N.A. 85.5 N.A. N.A. 62.7 N.A. N.A. 58.5 N.A. 35.7 34.3 35.9 43
P-Site Identity: 100 100 6.6 93.3 N.A. 6.6 N.A. N.A. 6.6 N.A. N.A. 6.6 N.A. 6.6 0 0 13.3
P-Site Similarity: 100 100 13.3 93.3 N.A. 20 N.A. N.A. 13.3 N.A. N.A. 26.6 N.A. 20 0 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 28 10 0 0 0 0 0 19 10 19 10 0 37 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 10 0 0 10 10 0 0 0 0 28 10 0 0 % D
% Glu: 0 0 0 10 0 0 0 0 0 0 10 0 10 0 0 % E
% Phe: 0 0 0 10 10 10 10 0 0 0 0 0 0 0 10 % F
% Gly: 10 0 0 10 0 28 10 10 10 0 0 0 0 10 0 % G
% His: 0 0 0 10 0 0 10 10 0 28 10 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 10 0 10 28 % I
% Lys: 10 19 10 28 55 10 28 10 0 0 28 19 0 0 0 % K
% Leu: 37 10 0 0 0 19 0 0 28 10 0 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 28 0 10 % M
% Asn: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % N
% Pro: 10 0 0 0 0 10 10 19 10 10 0 0 0 0 0 % P
% Gln: 0 0 0 10 0 0 0 10 0 0 0 0 10 0 0 % Q
% Arg: 0 0 37 10 0 0 10 0 19 10 0 0 0 0 10 % R
% Ser: 0 0 0 0 0 0 0 28 0 10 0 0 10 0 10 % S
% Thr: 0 10 0 0 0 0 0 0 0 0 0 10 0 10 0 % T
% Val: 0 19 10 0 19 0 0 0 0 0 0 0 0 10 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _