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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIP5K1C
All Species:
22.73
Human Site:
S175
Identified Species:
55.56
UniProt:
O60331
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60331
NP_036530.1
668
73260
S175
S
N
P
G
A
S
G
S
L
F
Y
V
T
S
D
Chimpanzee
Pan troglodytes
XP_512274
753
81943
S264
S
N
P
G
A
S
G
S
L
F
Y
V
T
S
D
Rhesus Macaque
Macaca mulatta
NP_001130039
550
61219
V103
V
L
M
Q
D
F
Y
V
V
E
S
I
F
F
P
Dog
Lupus familis
XP_542172
761
83011
S273
S
N
P
G
A
S
G
S
L
F
Y
V
T
S
D
Cat
Felis silvestris
Mouse
Mus musculus
O70161
661
72390
S175
S
N
P
G
A
S
G
S
V
F
Y
V
T
S
D
Rat
Rattus norvegicus
Q5I6B8
688
75576
S175
S
N
P
G
A
S
G
S
V
F
Y
V
T
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511349
767
84935
S170
S
N
P
G
A
S
G
S
L
F
Y
V
T
S
D
Chicken
Gallus gallus
Q5ZJ58
540
60700
R92
T
Y
A
P
L
A
F
R
Y
F
R
E
L
F
G
Frog
Xenopus laevis
Q5PQ01
419
47633
Zebra Danio
Brachydanio rerio
Q6IQE1
416
47361
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.6
55.2
82.3
N.A.
91.3
87.2
N.A.
74.1
52.6
21.7
21.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
86.4
65.4
84
N.A.
94.3
90.6
N.A.
78.6
64.9
35.7
35.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
100
N.A.
93.3
93.3
N.A.
100
6.6
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
20
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
60
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
60
% D
% Glu:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
10
10
0
0
70
0
0
10
20
0
% F
% Gly:
0
0
0
60
0
0
60
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
10
0
0
0
40
0
0
0
10
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
60
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
60
10
0
0
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% R
% Ser:
60
0
0
0
0
60
0
60
0
0
10
0
0
60
0
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
0
60
0
0
% T
% Val:
10
0
0
0
0
0
0
10
30
0
0
60
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
10
0
10
0
60
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _