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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FZD6
All Species:
18.18
Human Site:
S535
Identified Species:
40
UniProt:
O60353
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60353
NP_001158087.1
706
79292
S535
E
F
F
L
K
H
N
S
K
V
K
H
K
K
K
Chimpanzee
Pan troglodytes
XP_001156717
706
79402
S535
E
F
F
L
K
H
N
S
K
V
K
H
K
K
K
Rhesus Macaque
Macaca mulatta
XP_001085270
706
79303
S535
E
F
F
L
K
H
N
S
K
V
K
H
K
K
K
Dog
Lupus familis
XP_543219
666
76260
F496
I
V
G
I
P
S
I
F
W
V
G
S
K
K
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61089
709
79063
S535
E
F
F
L
K
H
N
S
K
V
K
H
K
K
K
Rat
Rattus norvegicus
NP_001124008
710
79086
S535
E
F
F
L
K
H
N
S
K
V
R
H
K
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511570
650
72908
H480
K
H
N
S
K
V
K
H
K
K
K
H
Y
K
S
Chicken
Gallus gallus
O57328
592
65472
L422
G
Q
V
D
G
D
V
L
S
G
V
C
F
V
G
Frog
Xenopus laevis
O42579
664
75600
V494
L
V
V
G
I
P
S
V
F
W
V
G
S
K
K
Zebra Danio
Brachydanio rerio
NP_001074070
667
75737
L497
V
L
F
L
I
K
Y
L
M
V
L
V
V
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18537
581
64829
V411
E
G
D
I
L
S
G
V
C
F
V
G
Q
L
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
98.4
50.4
N.A.
82.9
84.7
N.A.
75.2
33.9
50.4
50.1
N.A.
34.4
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
99.2
64.3
N.A.
89
89.8
N.A.
80.1
48
63.5
64.3
N.A.
46.1
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
20
N.A.
100
93.3
N.A.
33.3
0
13.3
20
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
40
0
20
20
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% C
% Asp:
0
0
10
10
0
10
0
0
0
0
0
0
0
0
10
% D
% Glu:
55
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
46
55
0
0
0
0
10
10
10
0
0
10
0
0
% F
% Gly:
10
10
10
10
10
0
10
0
0
10
10
19
0
10
10
% G
% His:
0
10
0
0
0
46
0
10
0
0
0
55
0
0
0
% H
% Ile:
10
0
0
19
19
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
10
0
0
0
55
10
10
0
55
10
46
0
55
73
55
% K
% Leu:
10
10
0
55
10
0
0
19
0
0
10
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
46
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
0
0
10
0
19
10
46
10
0
0
10
10
0
10
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
10
19
19
0
0
10
10
19
0
64
28
10
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _