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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FZD6 All Species: 14.55
Human Site: S548 Identified Species: 32
UniProt: O60353 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60353 NP_001158087.1 706 79292 S548 K K H Y K P S S H K L K V I S
Chimpanzee Pan troglodytes XP_001156717 706 79402 S548 K K H Y K P S S H K L K V I S
Rhesus Macaque Macaca mulatta XP_001085270 706 79303 S548 K K H Y K P S S H K L K V I S
Dog Lupus familis XP_543219 666 76260 S509 K T C F E W A S F F H G R R K
Cat Felis silvestris
Mouse Mus musculus Q61089 709 79063 P548 K K H G A P G P H R L K V I S
Rat Rattus norvegicus NP_001124008 710 79086 S548 K K H G K P G S H K L K V I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511570 650 72908 K493 K S S S H K L K V I S K S M G
Chicken Gallus gallus O57328 592 65472 A435 V G I N N V D A L R G F V L A
Frog Xenopus laevis O42579 664 75600 A507 K K T C F E W A S F F H G R K
Zebra Danio Brachydanio rerio NP_001074070 667 75737 V510 G I P S V F W V G S K K T C F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18537 581 64829 A424 L D T H S L G A F L I L P L C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 98.4 50.4 N.A. 82.9 84.7 N.A. 75.2 33.9 50.4 50.1 N.A. 34.4 N.A. N.A. N.A.
Protein Similarity: 100 99.5 99.2 64.3 N.A. 89 89.8 N.A. 80.1 48 63.5 64.3 N.A. 46.1 N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 66.6 86.6 N.A. 13.3 6.6 13.3 6.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 33.3 N.A. 73.3 86.6 N.A. 20 33.3 20 6.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 10 28 0 0 0 0 0 0 10 % A
% Cys: 0 0 10 10 0 0 0 0 0 0 0 0 0 10 10 % C
% Asp: 0 10 0 0 0 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 10 10 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 10 10 0 0 19 19 10 10 0 0 10 % F
% Gly: 10 10 0 19 0 0 28 0 10 0 10 10 10 0 10 % G
% His: 0 0 46 10 10 0 0 0 46 0 10 10 0 0 0 % H
% Ile: 0 10 10 0 0 0 0 0 0 10 10 0 0 46 0 % I
% Lys: 73 55 0 0 37 10 0 10 0 37 10 64 0 0 19 % K
% Leu: 10 0 0 0 0 10 10 0 10 10 46 10 0 19 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 0 46 0 10 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 19 0 0 10 19 0 % R
% Ser: 0 10 10 19 10 0 28 46 10 10 10 0 10 0 46 % S
% Thr: 0 10 19 0 0 0 0 0 0 0 0 0 10 0 0 % T
% Val: 10 0 0 0 10 10 0 10 10 0 0 0 55 0 0 % V
% Trp: 0 0 0 0 0 10 19 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _