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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TPST1
All Species:
33.94
Human Site:
Y65
Identified Species:
67.88
UniProt:
O60507
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60507
NP_003587.1
370
42188
Y65
K
A
N
K
T
F
A
Y
H
K
D
M
P
L
I
Chimpanzee
Pan troglodytes
XP_001172350
377
41866
Y64
T
N
H
V
E
Y
R
Y
G
K
A
M
P
L
I
Rhesus Macaque
Macaca mulatta
XP_001086632
370
42168
Y65
K
A
N
K
T
F
A
Y
H
K
D
M
P
L
I
Dog
Lupus familis
XP_546906
370
42192
Y65
K
A
N
K
T
F
A
Y
H
K
D
M
P
L
I
Cat
Felis silvestris
Mouse
Mus musculus
O70281
370
42114
Y65
K
A
N
K
T
F
T
Y
H
K
D
M
P
L
I
Rat
Rattus norvegicus
Q3KR92
370
42117
Y65
K
A
N
K
T
F
T
Y
H
K
N
M
P
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJI0
371
42023
Y62
S
N
H
V
E
Y
R
Y
S
K
E
M
P
L
I
Frog
Xenopus laevis
NP_001085590
372
42191
K65
N
S
N
F
T
Y
D
K
D
M
P
L
I
F
I
Zebra Danio
Brachydanio rerio
Q9PTE6
355
40179
Y62
N
L
S
T
P
F
I
Y
N
K
D
M
P
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VYB7
499
58032
Y66
D
N
Q
R
V
Y
S
Y
N
R
E
M
P
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O77081
380
43295
Y65
S
V
R
S
D
D
G
Y
N
R
T
S
P
F
I
Sea Urchin
Strong. purpuratus
XP_001190618
798
90248
Y55
D
A
N
N
E
Y
T
Y
H
R
E
M
P
L
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.1
99.1
97.5
N.A.
96.4
96.2
N.A.
N.A.
64.9
87.3
79.7
N.A.
44.6
N.A.
52.1
28.9
Protein Similarity:
100
77.4
99.7
99.7
N.A.
98.3
98.6
N.A.
N.A.
79.7
93.5
88.6
N.A.
56.9
N.A.
69.2
36.5
P-Site Identity:
100
40
100
100
N.A.
93.3
86.6
N.A.
N.A.
40
20
53.3
N.A.
33.3
N.A.
20
53.3
P-Site Similarity:
100
53.3
100
100
N.A.
93.3
93.3
N.A.
N.A.
60
40
66.6
N.A.
73.3
N.A.
33.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
50
0
0
0
0
25
0
0
0
9
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
0
9
9
9
0
9
0
42
0
0
0
0
% D
% Glu:
0
0
0
0
25
0
0
0
0
0
25
0
0
0
0
% E
% Phe:
0
0
0
9
0
50
0
0
0
0
0
0
0
17
0
% F
% Gly:
0
0
0
0
0
0
9
0
9
0
0
0
0
0
0
% G
% His:
0
0
17
0
0
0
0
0
50
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
100
% I
% Lys:
42
0
0
42
0
0
0
9
0
67
0
0
0
0
0
% K
% Leu:
0
9
0
0
0
0
0
0
0
0
0
9
0
84
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
84
0
0
0
% M
% Asn:
17
25
59
9
0
0
0
0
25
0
9
0
0
0
0
% N
% Pro:
0
0
0
0
9
0
0
0
0
0
9
0
92
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
9
9
0
0
17
0
0
25
0
0
0
0
0
% R
% Ser:
17
9
9
9
0
0
9
0
9
0
0
9
0
0
0
% S
% Thr:
9
0
0
9
50
0
25
0
0
0
9
0
0
0
0
% T
% Val:
0
9
0
17
9
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
42
0
92
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _