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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E2 All Species: 23.94
Human Site: S13 Identified Species: 37.62
UniProt: O60573 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60573 NP_004837.1 245 28362 S13 D A L K D D D S G D H D Q N E
Chimpanzee Pan troglodytes XP_516153 236 27201 S13 D A L K D D D S G D H D Q N E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545602 245 28254 S13 N T L K D D D S G G H D Q N E
Cat Felis silvestris
Mouse Mus musculus Q8BMB3 245 28244 S13 D A L K D D D S G D H D Q N E
Rat Rattus norvegicus P63074 217 25035 T8 M A T V E P E T T P T T N P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232426 247 28450 S13 D A L K D D D S G D H D Q N E
Frog Xenopus laevis P48597 213 24616 N10 A V E P E N T N P Q S T E E E
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 T8 M A T A E P E T S T N P S N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 S35 G R P E P P T S A A A P A E A
Honey Bee Apis mellifera XP_623570 273 31794 N18 R L K A N E D N G D D E T Q S
Nematode Worm Caenorhab. elegans Q22888 212 24566 Q8 M E A E T S T Q E V V K Q V K
Sea Urchin Strong. purpuratus NP_001077102 227 26298 S10 V Q L K D D D S G E E R E E V
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 R8 M A E E T D T R P A S A G S R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FK59 221 25726 N16 D E I R D S G N M D S I K S H
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 E11 E E V S K K F E E N V S V D D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.4 N.A. 95.9 N.A. 98.3 28.9 N.A. N.A. 87.8 29.3 29.3 N.A. 28.9 55.6 43.2 61.6
Protein Similarity: 100 92.2 N.A. 97.1 N.A. 99.5 49.3 N.A. N.A. 91.5 50.6 49.3 N.A. 50.1 67.7 57.9 71.4
P-Site Identity: 100 100 N.A. 80 N.A. 100 6.6 N.A. N.A. 100 6.6 13.3 N.A. 6.6 20 6.6 46.6
P-Site Similarity: 100 100 N.A. 86.6 N.A. 100 26.6 N.A. N.A. 100 33.3 40 N.A. 13.3 46.6 20 60
Percent
Protein Identity: N.A. 32.6 N.A. 41.6 28.1 N.A.
Protein Similarity: N.A. 53.8 N.A. 58.7 48.1 N.A.
P-Site Identity: N.A. 13.3 N.A. 20 0 N.A.
P-Site Similarity: N.A. 26.6 N.A. 53.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 47 7 14 0 0 0 0 7 14 7 7 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 34 0 0 0 47 47 47 0 0 40 7 34 0 7 7 % D
% Glu: 7 20 14 20 20 7 14 7 14 7 7 7 14 20 40 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 0 7 0 47 7 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 34 0 0 0 7 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 7 40 7 7 0 0 0 0 0 7 7 0 7 % K
% Leu: 0 7 40 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 27 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 7 0 20 0 7 7 0 7 40 0 % N
% Pro: 0 0 7 7 7 20 0 0 14 7 0 14 0 7 7 % P
% Gln: 0 7 0 0 0 0 0 7 0 7 0 0 40 7 0 % Q
% Arg: 7 7 0 7 0 0 0 7 0 0 0 7 0 0 7 % R
% Ser: 0 0 0 7 0 14 0 47 7 0 20 7 7 14 14 % S
% Thr: 0 7 14 0 14 0 27 14 7 7 7 14 7 0 0 % T
% Val: 7 7 7 7 0 0 0 0 0 7 14 0 7 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _