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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF4E2 All Species: 30.91
Human Site: S145 Identified Species: 48.57
UniProt: O60573 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60573 NP_004837.1 245 28362 S145 R L R K G L A S R C W E N L I
Chimpanzee Pan troglodytes XP_516153 236 27201 S145 R L R K G L A S R C W E N L I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545602 245 28254 S145 R L R K G L A S R C W E N L I
Cat Felis silvestris
Mouse Mus musculus Q8BMB3 245 28244 S145 R L R K G L A S R C W E N L I
Rat Rattus norvegicus P63074 217 25035 D127 Q Q R R S D L D R F W L E T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232426 247 28450 S145 R L R K G L A S R C W E N L I
Frog Xenopus laevis P48597 213 24616 E136 T L M C L I G E S F D E H S D
Zebra Danio Brachydanio rerio Q9DFS6 215 24831 E138 T L L C L V G E A F D D H S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48598 259 29205 D170 K S S K T D L D N L W L D V L
Honey Bee Apis mellifera XP_623570 273 31794 S137 R L R K G L V S R C W E N L I
Nematode Worm Caenorhab. elegans Q22888 212 24566 T121 R L K K G L S T R I W E N L L
Sea Urchin Strong. purpuratus NP_001077102 227 26298 S137 R L R K G L A S R L W E N L V
Poplar Tree Populus trichocarpa
Maize Zea mays O81481 218 24452 D132 S C G R G K S D T F W L H T L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FK59 221 25726 A132 R F S K V V S A R F W E D L L
Baker's Yeast Sacchar. cerevisiae P07260 213 24236 A136 L W L R T L L A V I G E T I D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.4 N.A. 95.9 N.A. 98.3 28.9 N.A. N.A. 87.8 29.3 29.3 N.A. 28.9 55.6 43.2 61.6
Protein Similarity: 100 92.2 N.A. 97.1 N.A. 99.5 49.3 N.A. N.A. 91.5 50.6 49.3 N.A. 50.1 67.7 57.9 71.4
P-Site Identity: 100 100 N.A. 100 N.A. 100 20 N.A. N.A. 100 13.3 6.6 N.A. 13.3 93.3 66.6 86.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 40 N.A. N.A. 100 26.6 26.6 N.A. 40 93.3 93.3 93.3
Percent
Protein Identity: N.A. 32.6 N.A. 41.6 28.1 N.A.
Protein Similarity: N.A. 53.8 N.A. 58.7 48.1 N.A.
P-Site Identity: N.A. 13.3 N.A. 40 13.3 N.A.
P-Site Similarity: N.A. 40 N.A. 73.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 40 14 7 0 0 0 0 0 0 % A
% Cys: 0 7 0 14 0 0 0 0 0 40 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 14 0 20 0 0 14 7 14 0 20 % D
% Glu: 0 0 0 0 0 0 0 14 0 0 0 74 7 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 34 0 0 0 0 0 % F
% Gly: 0 0 7 0 60 0 14 0 0 0 7 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % H
% Ile: 0 0 0 0 0 7 0 0 0 14 0 0 0 7 40 % I
% Lys: 7 0 7 67 0 7 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 67 14 0 14 60 20 0 0 14 0 20 0 60 34 % L
% Met: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 7 0 0 0 54 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 60 0 54 20 0 0 0 0 67 0 0 0 0 0 0 % R
% Ser: 7 7 14 0 7 0 20 47 7 0 0 0 0 14 0 % S
% Thr: 14 0 0 0 14 0 0 7 7 0 0 0 7 14 0 % T
% Val: 0 0 0 0 7 14 7 0 7 0 0 0 0 7 7 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 80 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _