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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4E2
All Species:
21.21
Human Site:
S41
Identified Species:
33.33
UniProt:
O60573
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60573
NP_004837.1
245
28362
S41
E
R
D
K
N
Q
S
S
S
K
R
K
A
V
V
Chimpanzee
Pan troglodytes
XP_516153
236
27201
S41
E
R
D
K
N
Q
S
S
S
K
R
K
A
V
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545602
245
28254
S41
E
R
D
K
S
Q
G
S
S
N
R
K
A
V
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BMB3
245
28244
S41
D
R
D
K
S
Q
S
S
G
K
R
K
A
V
V
Rat
Rattus norvegicus
P63074
217
25035
K36
A
N
P
E
H
Y
I
K
H
P
L
Q
N
R
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232426
247
28450
T41
D
R
E
K
P
Q
S
T
T
K
R
K
A
V
V
Frog
Xenopus laevis
P48597
213
24616
R38
I
K
H
P
L
Q
N
R
W
A
L
W
F
F
K
Zebra Danio
Brachydanio rerio
Q9DFS6
215
24831
P36
L
E
D
Y
I
K
H
P
L
Q
N
R
W
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48598
259
29205
T63
E
P
A
G
N
T
A
T
T
T
A
P
A
G
D
Honey Bee
Apis mellifera
XP_623570
273
31794
H46
I
E
I
N
P
N
E
H
K
L
Q
Y
A
Y
A
Nematode Worm
Caenorhab. elegans
Q22888
212
24566
S36
D
D
H
Q
L
Q
Y
S
Y
T
F
S
Y
F
M
Sea Urchin
Strong. purpuratus
NP_001077102
227
26298
T38
P
H
Q
I
E
W
P
T
V
K
C
K
Q
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O81481
218
24452
A36
E
I
T
D
L
A
C
A
P
S
P
P
A
T
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FK59
221
25726
P44
E
L
K
D
G
D
H
P
L
R
Y
K
F
S
I
Baker's Yeast
Sacchar. cerevisiae
P07260
213
24236
L39
H
F
D
V
K
H
P
L
N
T
K
W
T
L
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.4
N.A.
95.9
N.A.
98.3
28.9
N.A.
N.A.
87.8
29.3
29.3
N.A.
28.9
55.6
43.2
61.6
Protein Similarity:
100
92.2
N.A.
97.1
N.A.
99.5
49.3
N.A.
N.A.
91.5
50.6
49.3
N.A.
50.1
67.7
57.9
71.4
P-Site Identity:
100
100
N.A.
80
N.A.
80
0
N.A.
N.A.
66.6
6.6
6.6
N.A.
20
6.6
13.3
13.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
93.3
20
N.A.
N.A.
93.3
20
33.3
N.A.
40
13.3
33.3
20
Percent
Protein Identity:
N.A.
32.6
N.A.
41.6
28.1
N.A.
Protein Similarity:
N.A.
53.8
N.A.
58.7
48.1
N.A.
P-Site Identity:
N.A.
13.3
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
7
7
7
0
7
7
0
54
7
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% C
% Asp:
20
7
40
14
0
7
0
0
0
0
0
0
0
0
7
% D
% Glu:
40
14
7
7
7
0
7
0
0
0
0
0
0
0
7
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
7
0
14
14
0
% F
% Gly:
0
0
0
7
7
0
7
0
7
0
0
0
0
14
0
% G
% His:
7
7
14
0
7
7
14
7
7
0
0
0
0
0
7
% H
% Ile:
14
7
7
7
7
0
7
0
0
0
0
0
0
0
7
% I
% Lys:
0
7
7
34
7
7
0
7
7
34
7
47
0
0
7
% K
% Leu:
7
7
0
0
20
0
0
7
14
7
14
0
0
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
7
0
7
20
7
7
0
7
7
7
0
7
0
0
% N
% Pro:
7
7
7
7
14
0
14
14
7
7
7
14
0
0
0
% P
% Gln:
0
0
7
7
0
47
0
0
0
7
7
7
7
0
0
% Q
% Arg:
0
34
0
0
0
0
0
7
0
7
34
7
0
7
0
% R
% Ser:
0
0
0
0
14
0
27
34
20
7
0
7
0
7
0
% S
% Thr:
0
0
7
0
0
7
0
20
14
20
0
0
7
7
0
% T
% Val:
0
0
0
7
0
0
0
0
7
0
0
0
0
34
34
% V
% Trp:
0
0
0
0
0
7
0
0
7
0
0
14
7
0
14
% W
% Tyr:
0
0
0
7
0
7
7
0
7
0
7
7
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _